Product inhibition can accelerate evolution
Molecular replicators studied in-vitro exhibit product inhibition, typically caused by the hybridization of products into dimer complex that are not able to replicate. As a result, the replication rate and the selection pressure is reduced, potentially allowing the “survival of everyone”. Here, we introduce a stochastic evolution model of replicating and hybridizing RNA strands to study the effect of product inhibition on evolution. We found that hybridization, though reducing the rate of replication, can increase the rate of evolution, measured as fitness gain within a period of time. The positive effect has been observed for a mutation error smaller than half of the error threshold. In this situation, frequency-dependent competition causes an increased diversity that spreads not only within a neutral network but also over various neutral networks through a dynamical modulation of the fitness landscape, resulting in a more effective search for better replicators. The underlying model is inspired by RNA virus replication and the RNA world hypothesis. Further investigations are needed to validate the actual effect of accelerated evolution through product inhibition in those systems.Significance Statement In this paper we present a novel evolutionary phenomenon, where product inhibition, though reducing the effective replication rate, can accelerate the rate of evolution. We show this phenomenon in a model of simulated single-stranded RNA (sRNA) sequence evolution extended by hybridization of sRNA, causing product inhibition. The evolutionary phenomenon could be relevant in (a) prebiotic evolution, where replicating polymers hypothetically emerged and where very likely subject to product inhibition, (b) biotic evolution, e.g., where RNA strands of viruses replicate within a biological cell, or (c) artificial molecular or chemical evolution, where product inhibition might be used to evolve molecules with desired properties more efficiently..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 06. Juli Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ruth, Beatrice [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2022.06.14.496101 |
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| PPN (Katalog-ID): |
XBI036305944 |
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| 520 | |a Molecular replicators studied in-vitro exhibit product inhibition, typically caused by the hybridization of products into dimer complex that are not able to replicate. As a result, the replication rate and the selection pressure is reduced, potentially allowing the “survival of everyone”. Here, we introduce a stochastic evolution model of replicating and hybridizing RNA strands to study the effect of product inhibition on evolution. We found that hybridization, though reducing the rate of replication, can increase the rate of evolution, measured as fitness gain within a period of time. The positive effect has been observed for a mutation error smaller than half of the error threshold. In this situation, frequency-dependent competition causes an increased diversity that spreads not only within a neutral network but also over various neutral networks through a dynamical modulation of the fitness landscape, resulting in a more effective search for better replicators. The underlying model is inspired by RNA virus replication and the RNA world hypothesis. Further investigations are needed to validate the actual effect of accelerated evolution through product inhibition in those systems.Significance Statement In this paper we present a novel evolutionary phenomenon, where product inhibition, though reducing the effective replication rate, can accelerate the rate of evolution. We show this phenomenon in a model of simulated single-stranded RNA (sRNA) sequence evolution extended by hybridization of sRNA, causing product inhibition. The evolutionary phenomenon could be relevant in (a) prebiotic evolution, where replicating polymers hypothetically emerged and where very likely subject to product inhibition, (b) biotic evolution, e.g., where RNA strands of viruses replicate within a biological cell, or (c) artificial molecular or chemical evolution, where product inhibition might be used to evolve molecules with desired properties more efficiently. | ||
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