Containment of a multi-index B.1.1.7 outbreak on a university campus through a genomically-informed public health response
Abstract The first cluster of SARS-CoV-2 cases with lineage B.1.1.7 in the state of Michigan was identified through intensive university-led surveillance sampling and targeted sequencing. A collaborative investigation and response was conducted by the local and state health departments, and the campus and athletic medicine COVID-19 response teams, using S-gene target failure screening and rapid genomic sequencing to inform containment strategies. A total of 50 cases of B.1.1.7-lineage SARS-CoV-2 were identified in this outbreak, which was due to three coincident introductions of B.1.1.7-lineage SARS-CoV-2, all of which were genetically distinct from lineages which later circulated in the broader community. This investigation demonstrates the successful implementation of a genomically-informed outbreak response which can be extended to university campuses and other settings at high risk for rapid emergence of new variants..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 08. Jan. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martin, Emily T. [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2022.01.04.22268758 |
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| PPN (Katalog-ID): |
XBI033355789 |
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| 245 | 1 | 0 | |a Containment of a multi-index B.1.1.7 outbreak on a university campus through a genomically-informed public health response |
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| 520 | |a Abstract The first cluster of SARS-CoV-2 cases with lineage B.1.1.7 in the state of Michigan was identified through intensive university-led surveillance sampling and targeted sequencing. A collaborative investigation and response was conducted by the local and state health departments, and the campus and athletic medicine COVID-19 response teams, using S-gene target failure screening and rapid genomic sequencing to inform containment strategies. A total of 50 cases of B.1.1.7-lineage SARS-CoV-2 were identified in this outbreak, which was due to three coincident introductions of B.1.1.7-lineage SARS-CoV-2, all of which were genetically distinct from lineages which later circulated in the broader community. This investigation demonstrates the successful implementation of a genomically-informed outbreak response which can be extended to university campuses and other settings at high risk for rapid emergence of new variants. | ||
| 700 | 1 | |a Lauring, Adam S. |e verfasserin |4 aut | |
| 700 | 1 | |a Montgomery, JoLynn P. |e verfasserin |4 aut | |
| 700 | 1 | |a Valesano, Andrew L. |e verfasserin |4 aut | |
| 700 | 1 | |a Eisenberg, Marisa C. |e verfasserin |4 aut | |
| 700 | 1 | |a Sheen, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Nord, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Ernst, Robert D. |e verfasserin |4 aut | |
| 700 | 1 | |a Mortenson, Lindsey Y. |e verfasserin |4 aut | |
| 700 | 1 | |a Valdez, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Niknafs, Yashar |e verfasserin |4 aut | |
| 700 | 1 | |a Conway, Darryl |e verfasserin |4 aut | |
| 700 | 1 | |a Rifat, Sami F. |e verfasserin |4 aut | |
| 700 | 1 | |a Bagdasarian, Natasha |e verfasserin |4 aut | |
| 700 | 1 | |a Lyon-Callo, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Collins, Jim |e verfasserin |4 aut | |
| 700 | 1 | |a Blankenship, Heather |e verfasserin |4 aut | |
| 700 | 1 | |a Soehnlen, Marty |e verfasserin |4 aut | |
| 700 | 1 | |a Marquez, Juan |e verfasserin |4 aut | |
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