Improved neutralisation of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech (BNT162b2) COVID-19 vaccine boosting with a third dose
Abstract In late November 2021, the World Health Organization declared the SARS-CoV-2 lineage B.1.1.529 the fifth variant of concern, Omicron. This variant has acquired 15 mutations in the receptor binding domain of the spike protein, raising concerns that Omicron could evade naturally acquired and vaccine-derived immunity. We utilized an authentic virus, multicycle neutralisation assay to demonstrate that sera collected one, three and six months post-two doses of Pfizer-BioNTech BNT162b2 has a limited ability to neutralise SARS-CoV-2. However, four weeks after a third dose, neutralising antibody titres are boosted. Despite this increase, neutralising antibody titres are reduced four-fold for Omicron compared to lineage A.2.2 SARS-CoV-2..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 10. Aug. Zur Gesamtaufnahme - year:2022 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Basile, Kerri [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1101/2021.12.12.472252 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XBI033217270 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XBI033217270 | ||
| 003 | DE-627 | ||
| 005 | 20230429084302.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211215s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/2021.12.12.472252 |2 doi | |
| 035 | |a (DE-627)XBI033217270 | ||
| 035 | |a (biorXiv)10.1101/2021.12.12.472252 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Basile, Kerri |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Improved neutralisation of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech (BNT162b2) COVID-19 vaccine boosting with a third dose |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract In late November 2021, the World Health Organization declared the SARS-CoV-2 lineage B.1.1.529 the fifth variant of concern, Omicron. This variant has acquired 15 mutations in the receptor binding domain of the spike protein, raising concerns that Omicron could evade naturally acquired and vaccine-derived immunity. We utilized an authentic virus, multicycle neutralisation assay to demonstrate that sera collected one, three and six months post-two doses of Pfizer-BioNTech BNT162b2 has a limited ability to neutralise SARS-CoV-2. However, four weeks after a third dose, neutralising antibody titres are boosted. Despite this increase, neutralising antibody titres are reduced four-fold for Omicron compared to lineage A.2.2 SARS-CoV-2. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Rockett, Rebecca J |e verfasserin |4 aut | |
| 700 | 1 | |a McPhie, Kenneth |e verfasserin |4 aut | |
| 700 | 1 | |a Fennell, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson-Mackinnon, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Agius, Jessica E |e verfasserin |4 aut | |
| 700 | 1 | |a Fong, Winkie |e verfasserin |4 aut | |
| 700 | 1 | |a Rahman, Hossinur |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Danny |e verfasserin |4 aut | |
| 700 | 1 | |a Donavan, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Hueston, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Lam, Connie |e verfasserin |4 aut | |
| 700 | 1 | |a Arnott, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Sharon C-A |e verfasserin |4 aut | |
| 700 | 1 | |a Maddocks, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a O’Sullivan, Matthew V |e verfasserin |4 aut | |
| 700 | 1 | |a Dwyer, Dominic E |e verfasserin |4 aut | |
| 700 | 1 | |a Sintchenko, Vitali |e verfasserin |4 aut | |
| 700 | 1 | |a Kok, Jen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2022) vom: 10. Aug. |
| 773 | 1 | 8 | |g year:2022 |g day:10 |g month:08 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2021.12.12.472252 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2022 |b 10 |c 08 | ||