SARS-CoV-2 vaccination predicts COVID-19 progression and outcomes in hospitalized patients
ABSTRACT Background SARS-CoV-2 vaccination might impact on clinical progression of cases with breakthrough COVID-19 disease.Objective to evaluate the impact of SARS-CoV-2 vaccination on disease progression in COVID-19 hospitalized patientMethods and Findings Two-hundred eighty-four consecutive COVID-19 hospitalized patients, including 50 vaccinated cases entered the study. Compared to unvaccinated cases, vaccinated patients were older, exhibited more comorbidities and did not differ for COVID-19 severity at admission. During hospitalisation, unvaccinated patients showed worse disease progression, including higher need of oxygen and higher risk of death compared to vaccinated patients (OR 3.3; 1.05-10.7 95% CI in the whole cohort and OR 54.8; 3.5-852 in the ventilated cases).Discussion These findings argue for an important reduction in severity among vaccine breakthrough infection compared to unvaccinated cases in COVID-19 disease..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 29. Nov. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Padovani, Alessandro [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2021.11.21.21266633 |
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| PPN (Katalog-ID): |
XBI03309036X |
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| 520 | |a ABSTRACT Background SARS-CoV-2 vaccination might impact on clinical progression of cases with breakthrough COVID-19 disease.Objective to evaluate the impact of SARS-CoV-2 vaccination on disease progression in COVID-19 hospitalized patientMethods and Findings Two-hundred eighty-four consecutive COVID-19 hospitalized patients, including 50 vaccinated cases entered the study. Compared to unvaccinated cases, vaccinated patients were older, exhibited more comorbidities and did not differ for COVID-19 severity at admission. During hospitalisation, unvaccinated patients showed worse disease progression, including higher need of oxygen and higher risk of death compared to vaccinated patients (OR 3.3; 1.05-10.7 95% CI in the whole cohort and OR 54.8; 3.5-852 in the ventilated cases).Discussion These findings argue for an important reduction in severity among vaccine breakthrough infection compared to unvaccinated cases in COVID-19 disease. | ||
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