Second wave of the Covid-19 pandemic in Delhi, India: high seroprevalence not a deterrent?
ABSTRACT Background We report the findings of a large follow-up community-based serosurvey and correlating it with the COVID-19 test-positivity rate and the case load observed during the peak of the second wave of the Covid-19 pandemic in Delhi, India.Methods Individuals of age ≥5 years were recruited from 274 wards of the state (population ∼ 19.6 million) during January 11 to January 22’ 2021. A total of 100 participants each were included from all the wards for a net sample size of ∼28,000. A multi-stage sampling technique was applied for selection of participants for the household serosurvey. Anti SARS CoV-2 IgG antibodies were detected by using the VITROS assay (90% Sn, 100% Sp).Results Antibody positivity was observed in 14,298 (50.76%) of the 28,169 samples. The age, sex and district population weighted seroprevalence of the IgG SARS-CoV-2 was 50.52% (95% C.I. 49.94-51.10) and after adjustment for assay characteristics was 56.13% (95% C.I. 55.49-56.77). On adjusted analysis, participants aged ≥50 years, of female gender, housewives, having ever lived in containment zones, urban slum dwellers, and diabetes or hypertensive patients had significantly higher odds of SARS-CoV-2 antibody positivity.The peak infection rate and the test positivity rate since October 2020 were initially observed in mid-November 2020 with a subsequent steep declining trend, followed by a period of persistently low case burden lasting until the first week of March 2021. This was followed by a steady increase followed by an exponential surge in infections from April 2021 onwards culminating in the second wave of the pandemic.Conclusions The presence of infection induced immunity from SARS-CoV-2 even in more than one in two people can be ineffective in protecting the population..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 25. Mai Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sharma, Nandini [VerfasserIn] |
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| doi: |
10.1101/2021.09.09.21263331 |
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| PPN (Katalog-ID): |
XBI032566190 |
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| 520 | |a ABSTRACT Background We report the findings of a large follow-up community-based serosurvey and correlating it with the COVID-19 test-positivity rate and the case load observed during the peak of the second wave of the Covid-19 pandemic in Delhi, India.Methods Individuals of age ≥5 years were recruited from 274 wards of the state (population ∼ 19.6 million) during January 11 to January 22’ 2021. A total of 100 participants each were included from all the wards for a net sample size of ∼28,000. A multi-stage sampling technique was applied for selection of participants for the household serosurvey. Anti SARS CoV-2 IgG antibodies were detected by using the VITROS assay (90% Sn, 100% Sp).Results Antibody positivity was observed in 14,298 (50.76%) of the 28,169 samples. The age, sex and district population weighted seroprevalence of the IgG SARS-CoV-2 was 50.52% (95% C.I. 49.94-51.10) and after adjustment for assay characteristics was 56.13% (95% C.I. 55.49-56.77). On adjusted analysis, participants aged ≥50 years, of female gender, housewives, having ever lived in containment zones, urban slum dwellers, and diabetes or hypertensive patients had significantly higher odds of SARS-CoV-2 antibody positivity.The peak infection rate and the test positivity rate since October 2020 were initially observed in mid-November 2020 with a subsequent steep declining trend, followed by a period of persistently low case burden lasting until the first week of March 2021. This was followed by a steady increase followed by an exponential surge in infections from April 2021 onwards culminating in the second wave of the pandemic.Conclusions The presence of infection induced immunity from SARS-CoV-2 even in more than one in two people can be ineffective in protecting the population. | ||
| 700 | 1 | |a Sharma, Pragya |e verfasserin |4 aut | |
| 700 | 1 | |a Basu, Saurav |e verfasserin |4 aut | |
| 700 | 1 | |a Bakshi, Ritika |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Ekta |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Reshu |e verfasserin |4 aut | |
| 700 | 1 | |a Dushyant, Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Mundeja, Nutan |e verfasserin |4 aut | |
| 700 | 1 | |a Marak, Zeasley |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Sanjay |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Gautam Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Rustagi, Ruchir |e verfasserin |4 aut | |
| 700 | 1 | |a Sarin, S K |e verfasserin |4 aut | |
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