Detailed stratified GWAS analysis for severe COVID-19 in four European populations
ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic ∼0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5threlease of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, includingNAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 05. Jan. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1101/2021.07.21.21260624 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XBI032244541 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XBI032244541 | ||
| 003 | DE-627 | ||
| 005 | 20230429100548.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210724s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/2021.07.21.21260624 |2 doi | |
| 035 | |a (DE-627)XBI032244541 | ||
| 035 | |a (biorXiv)10.1101/2021.07.21.21260624 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Degenhardt, Frauke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Detailed stratified GWAS analysis for severe COVID-19 in four European populations |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic ∼0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5threlease of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, includingNAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Ellinghaus, David |e verfasserin |4 aut | |
| 700 | 1 | |a Juzenas, Simonas |e verfasserin |4 aut | |
| 700 | 1 | |a Lerga-Jaso, Jon |e verfasserin |4 aut | |
| 700 | 1 | |a Wendorff, Mareike |e verfasserin |4 aut | |
| 700 | 1 | |a Maya-Miles, Douglas |e verfasserin |4 aut | |
| 700 | 1 | |a Uellendahl-Werth, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a ElAbd, Hesham |e verfasserin |4 aut | |
| 700 | 1 | |a Rühlemann, Malte C |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Jatin |e verfasserin |4 aut | |
| 700 | 1 | |a Özer, Onur |e verfasserin |4 aut | |
| 700 | 1 | |a Lenning, Ole Bernt |e verfasserin |4 aut | |
| 700 | 1 | |a Myhre, Ronny |e verfasserin |4 aut | |
| 700 | 1 | |a Vadla, May Sissel |e verfasserin |4 aut | |
| 700 | 1 | |a Wacker, Eike M |e verfasserin |4 aut | |
| 700 | 1 | |a Wienbrandt, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Ortiz, Aaron Blandino |e verfasserin |4 aut | |
| 700 | 1 | |a de Salazar, Adolfo |e verfasserin |4 aut | |
| 700 | 1 | |a Chercoles, Adolfo Garrido |e verfasserin |4 aut | |
| 700 | 1 | |a Palom, Adriana |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz, Agustín |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Fernandez, Alba-Estela |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco-Grau, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Mantovani, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Zanella, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Holten, Aleksander Rygh |e verfasserin |4 aut | |
| 700 | 1 | |a Mayer, Alena |e verfasserin |4 aut | |
| 700 | 1 | |a Bandera, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Cherubini, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Protti, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Aghemo, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a Gerussi, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a Ramirez, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Alice |e verfasserin |4 aut | |
| 700 | 1 | |a Nebel, Almut |e verfasserin |4 aut | |
| 700 | 1 | |a Barreira, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Lleo, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Teles, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Kildal, Anders Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Biondi, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Caballero-Garralda, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Ganna, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Gori, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Glück, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Lind, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Tanck, Anja |e verfasserin |4 aut | |
| 700 | 1 | |a Hinney, Anke |e verfasserin |4 aut | |
| 700 | 1 | |a Nolla, Anna Carreras |e verfasserin |4 aut | |
| 700 | 1 | |a Fracanzani, Anna Ludovica |e verfasserin |4 aut | |
| 700 | 1 | |a Peschuck, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Cavallero, Annalisa |e verfasserin |4 aut | |
| 700 | 1 | |a Dyrhol-Riise, Anne Ma |e verfasserin |4 aut | |
| 700 | 1 | |a Ruello, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Julià, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Muscatello, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Pesenti, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Voza, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Rando-Segura, Ariadna |e verfasserin |4 aut | |
| 700 | 1 | |a Solier, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Axel |e verfasserin |4 aut | |
| 700 | 1 | |a Cortes, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Mateos, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Nafria-Jimenez, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Schaefer, Benedikt |e verfasserin |4 aut | |
| 700 | 1 | |a Jensen, Björn |e verfasserin |4 aut | |
| 700 | 1 | |a Bellinghausen, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Maj, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrando, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a de la Horra, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Quereda, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Skurk, Carsten |e verfasserin |4 aut | |
| 700 | 1 | |a Thibeault, Charlotte |e verfasserin |4 aut | |
| 700 | 1 | |a Scollo, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Herr, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Spinner, Christoph D |e verfasserin |4 aut | |
| 700 | 1 | |a Gassner, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Lange, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Cinzia |e verfasserin |4 aut | |
| 700 | 1 | |a Paccapelo, Cinzia |e verfasserin |4 aut | |
| 700 | 1 | |a Lehmann, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Angelini, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Cappadona, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Azuure, Clinton |e verfasserin |4 aut | |
| 700 | 1 | |a Bianco, Cristiana |e verfasserin |4 aut | |
| 700 | 1 | |a Cea, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Sancho, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Lihaug Hoff, Dag Arne |e verfasserin |4 aut | |
| 700 | 1 | |a Galimberti, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Prati, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Haschka, David |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez, David |e verfasserin |4 aut | |
| 700 | 1 | |a Pestaña, David |e verfasserin |4 aut | |
| 700 | 1 | |a Toapanta, David |e verfasserin |4 aut | |
| 700 | 1 | |a Muñiz-Diaz, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Azzolini, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Sandoval, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Binatti, Eleonora |e verfasserin |4 aut | |
| 700 | 1 | |a Scarpini, Elio |e verfasserin |4 aut | |
| 700 | 1 | |a Helbig, Elisa T |e verfasserin |4 aut | |
| 700 | 1 | |a Casalone, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Urrechaga, Eloisa |e verfasserin |4 aut | |
| 700 | 1 | |a Paraboschi, Elvezia Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Pontali, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Reverter, Enric |e verfasserin |4 aut | |
| 700 | 1 | |a Calderón, Enrique J |e verfasserin |4 aut | |
| 700 | 1 | |a Navas, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Solligård, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Contro, Ernesto |e verfasserin |4 aut | |
| 700 | 1 | |a Arana-Arri, Eunate |e verfasserin |4 aut | |
| 700 | 1 | |a Aziz, Fátima |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez, Félix García |e verfasserin |4 aut | |
| 700 | 1 | |a Ceriotti, Ferruccio |e verfasserin |4 aut | |
| 700 | 1 | |a Martinelli-Boneschi, Filippo |e verfasserin |4 aut | |
| 700 | 1 | |a Peyvandi, Flora |e verfasserin |4 aut | |
| 700 | 1 | |a Kurth, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Blasi, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Malvestiti, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Medrano, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Mesonero, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Frias, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Hanses, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Fredrik |e verfasserin |4 aut | |
| 700 | 1 | |a Hemmrich-Stanisak, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Bellani, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Grasselli, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Pezzoli, Gianni |e verfasserin |4 aut | |
| 700 | 1 | |a Costantino, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Albano, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Cardamone, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Bellelli, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Citerio, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Foti, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Lamorte, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Matullo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Baselli, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Kurihara, Hayato |e verfasserin |4 aut | |
| 700 | 1 | |a Neb, Holger |e verfasserin |4 aut | |
| 700 | 1 | |a My, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Kurth, Ingo |e verfasserin |4 aut | |
| 700 | 1 | |a Hernández, Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Pink, Isabell |e verfasserin |4 aut | |
| 700 | 1 | |a de Rojas, Itziar |e verfasserin |4 aut | |
| 700 | 1 | |a Galván-Femenia, Iván |e verfasserin |4 aut | |
| 700 | 1 | |a Holter, Jan Cato |e verfasserin |4 aut | |
| 700 | 1 | |a Afset, Jan Egil |e verfasserin |4 aut | |
| 700 | 1 | |a Heyckendorf, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Kässens, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Damås, Jan Kristian |e verfasserin |4 aut | |
| 700 | 1 | |a Rybniker, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Altmüller, Janine |e verfasserin |4 aut | |
| 700 | 1 | |a Ampuero, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Martín, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Erdmann, Jeanette |e verfasserin |4 aut | |
| 700 | 1 | |a Banales, Jesus M |e verfasserin |4 aut | |
| 700 | 1 | |a Badia, Joan Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Dopazo, Joaquin |e verfasserin |4 aut | |
| 700 | 1 | |a Schneider, Jochen |e verfasserin |4 aut | |
| 700 | 1 | |a Bergan, Jonas |e verfasserin |4 aut | |
| 700 | 1 | |a Barretina, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Walter, Jörn |e verfasserin |4 aut | |
| 700 | 1 | |a Quero, Jose Hernández |e verfasserin |4 aut | |
| 700 | 1 | |a Goikoetxea, Josune |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Guerrero, Juan M |e verfasserin |4 aut | |
| 700 | 1 | |a Fazaal, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Kraft, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Schröder, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Risnes, Kari |e verfasserin |4 aut | |
| 700 | 1 | |a Banasik, Karina |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Karl Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Gaede, Karoline I |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Etxebarria, Koldo |e verfasserin |4 aut | |
| 700 | 1 | |a Tonby, Kristian |e verfasserin |4 aut | |
| 700 | 1 | |a Heggelund, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Izquierdo-Sanchez, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Bettini, Laura Rachele |e verfasserin |4 aut | |
| 700 | 1 | |a Sumoy, Lauro |e verfasserin |4 aut | |
| 700 | 1 | |a Sander, Leif Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Lippert, Lena J |e verfasserin |4 aut | |
| 700 | 1 | |a Terranova, Leonardo |e verfasserin |4 aut | |
| 700 | 1 | |a Nkambule, Lindokuhle |e verfasserin |4 aut | |
| 700 | 1 | |a Knopp, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Gustad, Lise Tuset |e verfasserin |4 aut | |
| 700 | 1 | |a Garbarino, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Santoro, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Téllez, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Roade, Luisa |e verfasserin |4 aut | |
| 700 | 1 | |a Ostadreza, Mahnoosh |e verfasserin |4 aut | |
| 700 | 1 | |a Intxausti, Maider |e verfasserin |4 aut | |
| 700 | 1 | |a Kogevinas, Manolis |e verfasserin |4 aut | |
| 700 | 1 | |a Riveiro-Barciela, Mar |e verfasserin |4 aut | |
| 700 | 1 | |a Berger, Marc M |e verfasserin |4 aut | |
| 700 | 1 | |a Schaefer, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Niemi, Mari EK |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez-Stampa, María A |e verfasserin |4 aut | |
| 700 | 1 | |a Carrabba, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Figuera Basso, Maria E. |e verfasserin |4 aut | |
| 700 | 1 | |a Valsecchi, Maria Grazia |e verfasserin |4 aut | |
| 700 | 1 | |a Hernandez-Tejero, María |e verfasserin |4 aut | |
| 700 | 1 | |a Vehreschild, Maria JGT |e verfasserin |4 aut | |
| 700 | 1 | |a Manunta, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Acosta-Herrera, Marialbert |e verfasserin |4 aut | |
| 700 | 1 | |a D’Angiò, Mariella |e verfasserin |4 aut | |
| 700 | 1 | |a Baldini, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Cazzaniga, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Grimsrud, Marit M |e verfasserin |4 aut | |
| 700 | 1 | |a Cornberg, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Nöthen, Markus M |e verfasserin |4 aut | |
| 700 | 1 | |a Marquié, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Castoldi, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Cordioli, Mattia |e verfasserin |4 aut | |
| 700 | 1 | |a Cecconi, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a D’Amato, Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Augustin, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Tomasi, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Boada, Mercè |e verfasserin |4 aut | |
| 700 | 1 | |a Dreher, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Seilmaier, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Joannidis, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Wittig, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzocco, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccarelli, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Gandía, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Bocciolone, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Miozzo, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Ayo, Natale Imaz |e verfasserin |4 aut | |
| 700 | 1 | |a Blay, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Chueca, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Montano, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Ludwig, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Marx, Nikolaus |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, Nilda |e verfasserin |4 aut | |
| 700 | 1 | |a Cornely, Oliver A |e verfasserin |4 aut | |
| 700 | 1 | |a Witzke, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Palmieri, Orazio |e verfasserin |4 aut | |
| 700 | 1 | |a Faverio, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Preatoni, Paoletta |e verfasserin |4 aut | |
| 700 | 1 | |a Bonfanti, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Omodei, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Tentorio, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Pedro M |e verfasserin |4 aut | |
| 700 | 1 | |a España, Pedro Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffmann, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenstiel, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Schommers, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Suwalski, Phillip |e verfasserin |4 aut | |
| 700 | 1 | |a de Pablo, Raúl |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrer, Ricard |e verfasserin |4 aut | |
| 700 | 1 | |a Bals, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Gualtierotti, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Gallego-Durán, Rocío |e verfasserin |4 aut | |
| 700 | 1 | |a Nieto, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Carpani, Rossana |e verfasserin |4 aut | |
| 700 | 1 | |a Morilla, Rubén |e verfasserin |4 aut | |
| 700 | 1 | |a Badalamenti, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Haider, Sammra |e verfasserin |4 aut | |
| 700 | 1 | |a Ciesek, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a May, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Bombace, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Marsal, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Pigazzini, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Klein, Sebastian |e verfasserin |4 aut | |
| 700 | 1 | |a Pelusi, Serena |e verfasserin |4 aut | |
| 700 | 1 | |a Wilfling, Sibylle |e verfasserin |4 aut | |
| 700 | 1 | |a Bosari, Silvano |e verfasserin |4 aut | |
| 700 | 1 | |a Volland, Sonja |e verfasserin |4 aut | |
| 700 | 1 | |a Brunak, Søren |e verfasserin |4 aut | |
| 700 | 1 | |a Raychaudhuri, Soumya |e verfasserin |4 aut | |
| 700 | 1 | |a Schreiber, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Heilmann-Heimbach, Stefanie |e verfasserin |4 aut | |
| 700 | 1 | |a Aliberti, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Ripke, Stephan |e verfasserin |4 aut | |
| 700 | 1 | |a Dudman, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Wesse, Tanja |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Tenghao |e verfasserin |4 aut | |
| 700 | 1 | |a Bahmer, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Eggermann, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Illig, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Brenner, Thorsten |e verfasserin |4 aut | |
| 700 | 1 | |a Pumarola, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a Feldt, Torsten |e verfasserin |4 aut | |
| 700 | 1 | |a Folseraas, Trine |e verfasserin |4 aut | |
| 700 | 1 | |a Cejudo, Trinidad Gonzalez |e verfasserin |4 aut | |
| 700 | 1 | |a Landmesser, Ulf |e verfasserin |4 aut | |
| 700 | 1 | |a Protzer, Ulrike |e verfasserin |4 aut | |
| 700 | 1 | |a Hehr, Ute |e verfasserin |4 aut | |
| 700 | 1 | |a Rimoldi, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Monzani, Valter |e verfasserin |4 aut | |
| 700 | 1 | |a Skogen, Vegard |e verfasserin |4 aut | |
| 700 | 1 | |a Keitel, Verena |e verfasserin |4 aut | |
| 700 | 1 | |a Kopfnagel, Verena |e verfasserin |4 aut | |
| 700 | 1 | |a Friaza, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Andrade, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Albrecht, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Peter, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Poller, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Farre, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaomin |e verfasserin |4 aut | |
| 700 | 1 | |a Khodamoradi, Yascha |e verfasserin |4 aut | |
| 700 | 1 | |a Karadeniz, Zehra |e verfasserin |4 aut | |
| 700 | 1 | |a Latiano, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Goerg, Siegfried |e verfasserin |4 aut | |
| 700 | 1 | |a Bacher, Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Koehler, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Tran, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Zoller, Heinz |e verfasserin |4 aut | |
| 700 | 1 | |a Schulte, Eva C |e verfasserin |4 aut | |
| 700 | 1 | |a Heidecker, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Ludwig, Kerstin U |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Romero-Gómez, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Albillos, Agustín |e verfasserin |4 aut | |
| 700 | 1 | |a Invernizzi, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Buti, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Duga, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Bujanda, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Hov, Johannes R |e verfasserin |4 aut | |
| 700 | 1 | |a Lenz, Tobias L |e verfasserin |4 aut | |
| 700 | 1 | |a Asselta, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a de Cid, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Valenti, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Karlsen, Tom H |e verfasserin |4 aut | |
| 700 | 1 | |a Cáceres, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Franke, Andre |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2023) vom: 05. Jan. |
| 773 | 1 | 8 | |g year:2023 |g day:05 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2021.07.21.21260624 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 05 |c 01 | ||