Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 15. Dez. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Cesheng [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2021.04.05.437224 |
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| PPN (Katalog-ID): |
XBI020290179 |
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| 245 | 1 | 0 | |a Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan |
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| 520 | |a Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development. | ||
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| 700 | 1 | |a Wu, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Zhijun |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Taojing |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Junzheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Fengping |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Lianzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Huanhuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yue, Shenglan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Feifei |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zejun |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Jianhong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Ning, Haoran |e verfasserin |4 aut | |
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| 700 | 1 | |a Fu, Daoxing |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yanlin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Dongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Kai |e verfasserin |4 aut | |
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| 700 | 1 | |a Zhang, Xinxin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaoming |e verfasserin |4 aut | |
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