Characterization and safety profile of Imuno TF<sup>®</sup>, a nutritional supplement for immune system regulation containing transfer factors
Abstract Imuno TF®is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems, and historically is linked to the immune system regulation. In this study, we demonstrate for the first time its proteomic analysis, nutritional composition, and safety profile in terms of mutagenic potential and acute oral dose (LD50). The obtained analysis indicated the product is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. The chemical composition showed low fat and low sugar content, saturated fatty acids-free and the presence of 10 vitamins and 11 minerals. No mutagenic effect was observed, and the LD50was 5,000 mg kg-1body weight. This accounts for a safe product to be used by oral route, with potential benefits for the immune system..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 03. Dez. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Polonini, Hudson [VerfasserIn] |
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| doi: |
10.1101/2020.12.07.414169 |
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| PPN (Katalog-ID): |
XBI019489730 |
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| 520 | |a Abstract Imuno TF®is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems, and historically is linked to the immune system regulation. In this study, we demonstrate for the first time its proteomic analysis, nutritional composition, and safety profile in terms of mutagenic potential and acute oral dose (LD50). The obtained analysis indicated the product is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. The chemical composition showed low fat and low sugar content, saturated fatty acids-free and the presence of 10 vitamins and 11 minerals. No mutagenic effect was observed, and the LD50was 5,000 mg kg-1body weight. This accounts for a safe product to be used by oral route, with potential benefits for the immune system. | ||
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