Cerebellar rTMS in PSP: a double blind sham-controlled study using mobile health technology
SUMMARY There are no effective treatments for postural instability and falls in Progressive Supranuclear Palsy (PSP). Objective of the study was to test the efficacy of theta burst repetitive transcranial magnetic stimulation (rTMS) on postural instability in PSP. Twenty probable PSP patients underwent a session of sham or cerebellar rTMS in a cross-over design. Before and after stimulation, static balance was evaluated with instrumented (lower back accelerometer, Rehagait®, Hasomed, Germany) 30-seconds-trials in semitandem and tandem positions. In tandem and semitandem tasks, active stimulation was associated with longer time without support falls (both p=0.04). In the same tasks, device-extracted parameters revealed significant improvement in area (p=0.007), velocity (p=0.005) and acceleration and jerkiness of sway (p=0.008) in real versus sham stimulation. Cerebellar rTMS thus showed a significant effect on stability in PSP patients, when assessed with mobile digital technology, in a double-blind design. These results should motivate larger and longer trials using non-invasive brain stimulation for PSP patients..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 15. Dez. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pilotto, Andrea [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2020.11.09.20226068 |
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| PPN (Katalog-ID): |
XBI019330367 |
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| 520 | |a SUMMARY There are no effective treatments for postural instability and falls in Progressive Supranuclear Palsy (PSP). Objective of the study was to test the efficacy of theta burst repetitive transcranial magnetic stimulation (rTMS) on postural instability in PSP. Twenty probable PSP patients underwent a session of sham or cerebellar rTMS in a cross-over design. Before and after stimulation, static balance was evaluated with instrumented (lower back accelerometer, Rehagait®, Hasomed, Germany) 30-seconds-trials in semitandem and tandem positions. In tandem and semitandem tasks, active stimulation was associated with longer time without support falls (both p=0.04). In the same tasks, device-extracted parameters revealed significant improvement in area (p=0.007), velocity (p=0.005) and acceleration and jerkiness of sway (p=0.008) in real versus sham stimulation. Cerebellar rTMS thus showed a significant effect on stability in PSP patients, when assessed with mobile digital technology, in a double-blind design. These results should motivate larger and longer trials using non-invasive brain stimulation for PSP patients. | ||
| 700 | 1 | |a Rizzetti, Maria Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Lombardi, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Clint |e verfasserin |4 aut | |
| 700 | 1 | |a Biggi, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Verzeroli G, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Martinelli, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Romijnders, Robbin |e verfasserin |4 aut | |
| 700 | 1 | |a Borroni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Maetzler, Walter |e verfasserin |4 aut | |
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