Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Summary The SARS-CoV-2 pandemic is continuing to disrupt personal lives, global healthcare systems and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques. The vaccine-induced immunity protected macaques against a high dose challenge, resulting in strongly reduced viral infection and replication in upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 27. Nov. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| doi: |
10.1101/2020.11.07.365726 |
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| PPN (Katalog-ID): |
XBI019291175 |
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| 245 | 1 | 0 | |a Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection |
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| 520 | |a Summary The SARS-CoV-2 pandemic is continuing to disrupt personal lives, global healthcare systems and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques. The vaccine-induced immunity protected macaques against a high dose challenge, resulting in strongly reduced viral infection and replication in upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic. | ||
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| 700 | 1 | |a Brinkkemper, Mitch |e verfasserin |4 aut | |
| 700 | 1 | |a Maisonnasse, Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Dereuddre-Bosquet, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Grobben, Marloes |e verfasserin |4 aut | |
| 700 | 1 | |a Claireaux, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a de Gast, Marlon |e verfasserin |4 aut | |
| 700 | 1 | |a Marlin, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Chesnais, Virginie |e verfasserin |4 aut | |
| 700 | 1 | |a Diry, Ségolène |e verfasserin |4 aut | |
| 700 | 1 | |a Allen, Joel D. |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Yasunori |e verfasserin |4 aut | |
| 700 | 1 | |a Giezen, Julia M. |e verfasserin |4 aut | |
| 700 | 1 | |a Kerster, Gius |e verfasserin |4 aut | |
| 700 | 1 | |a Turner, Hannah L. |e verfasserin |4 aut | |
| 700 | 1 | |a van der Straten, Karlijn |e verfasserin |4 aut | |
| 700 | 1 | |a van der Linden, Cynthia A. |e verfasserin |4 aut | |
| 700 | 1 | |a Aldon, Yoann |e verfasserin |4 aut | |
| 700 | 1 | |a Naninck, Thibaut |e verfasserin |4 aut | |
| 700 | 1 | |a Bontjer, Ilja |e verfasserin |4 aut | |
| 700 | 1 | |a Burger, Judith A. |e verfasserin |4 aut | |
| 700 | 1 | |a Poniman, Meliawati |e verfasserin |4 aut | |
| 700 | 1 | |a Mykytyn, Anna Z. |e verfasserin |4 aut | |
| 700 | 1 | |a Okba, Nisreen M. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Schermer, Edith E. |e verfasserin |4 aut | |
| 700 | 1 | |a van Breemen, Marielle J. |e verfasserin |4 aut | |
| 700 | 1 | |a Ravichandran, Rashmi |e verfasserin |4 aut | |
| 700 | 1 | |a Caniels, Tom G. |e verfasserin |4 aut | |
| 700 | 1 | |a van Schooten, Jelle |e verfasserin |4 aut | |
| 700 | 1 | |a Kahlaoui, Nidhal |e verfasserin |4 aut | |
| 700 | 1 | |a Contreras, Vanessa |e verfasserin |4 aut | |
| 700 | 1 | |a Lemaître, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Chapon, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Ho Tsong Fang, Raphaël |e verfasserin |4 aut | |
| 700 | 1 | |a Villaudy, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Sliepen, Kwinten |e verfasserin |4 aut | |
| 700 | 1 | |a van der Velden, Yme U. |e verfasserin |4 aut | |
| 700 | 1 | |a Haagmans, Bart L. |e verfasserin |4 aut | |
| 700 | 1 | |a de Bree, Godelieve J. |e verfasserin |4 aut | |
| 700 | 1 | |a Ginoux, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Andrew B. |e verfasserin |4 aut | |
| 700 | 1 | |a Crispin, Max |e verfasserin |4 aut | |
| 700 | 1 | |a King, Neil P. |e verfasserin |4 aut | |
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| 700 | 1 | |a van Gils, Marit J. |e verfasserin |4 aut | |
| 700 | 1 | |a Grand, Roger Le |e verfasserin |4 aut | |
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