Co-infection of influenza A virus enhances SARS-CoV-2 infectivity
Abstract The upcoming flu season in the northern hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental co-infection of IAV with either pseudotyped or SARS-CoV-2 live virus, we found that IAV pre-infection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice co-infected with IAVin vivo. Moreover, such enhancement of SARS-CoV-2 infectivity was not seen with several other viruses probably due to a unique IAV segment as an inducer to elevate ACE2 expression. This study illustrates that IAV has a special nature to aggravate SARS-CoV-2 infection, and prevention of IAV is of great significance during the COVID-19 pandemic..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 23. Nov. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bai, Lei [VerfasserIn] |
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| doi: |
10.1101/2020.10.14.335893 |
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| PPN (Katalog-ID): |
XBI019129807 |
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| 245 | 1 | 0 | |a Co-infection of influenza A virus enhances SARS-CoV-2 infectivity |
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| 520 | |a Abstract The upcoming flu season in the northern hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental co-infection of IAV with either pseudotyped or SARS-CoV-2 live virus, we found that IAV pre-infection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice co-infected with IAVin vivo. Moreover, such enhancement of SARS-CoV-2 infectivity was not seen with several other viruses probably due to a unique IAV segment as an inducer to elevate ACE2 expression. This study illustrates that IAV has a special nature to aggravate SARS-CoV-2 infection, and prevention of IAV is of great significance during the COVID-19 pandemic. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
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| 700 | 1 | |a Zhao, Yongliang |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jiazhen |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Simeng |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xinjin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Zhixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Xiaoyi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhen |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Lianghui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qianyun |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yucheng |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Danping |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Jiajie |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Wenchao |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Zhidong |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Mingliang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Ke |e verfasserin |4 aut | |
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