Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection
Abstract Background Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through their contact with vulnerable patients. Smell loss has been associated with SARS-CoV-2 infection, but it is unknown whether monitoring for smell loss can be used to identify asymptomatic infection among high risk individuals, like HCW.Methods We performed a prospective cohort study, tracking 473 HCW across three months to determine if smell loss could predict SARS-CoV-2 infection in this high-risk group. HCW subjects completed a longitudinal, novel behavioral at-home assessment of smell function with household items, as well as detailed symptom surveys that included a parosmia screening questionnaire, and RT-qPCR testing to identify SARSCoV-2 infection.Results SARS-CoV-2 was identified in 17 (3.6%) of 473 HCW. Among the 17 infected HCW, 53% reported smell loss, and were more likely to report smell loss than COVID-negative HCW on both the at-home assessment and the screening questionnaire (P< .01). 67% reported smell loss prior to having a positive SARS-CoV-2 test, and smell loss was reported a median of two days before testing positive. Neurological symptoms were reported more frequently among COVID-positive HCW who reported smell loss (P< .01).Conclusions In this prospective study of HCW, self-reported changes in smell using two different measures were predictive of COVID-19 infection. Smell loss frequently preceded a positive test and was associated with neurological symptoms..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 17. Nov. Zur Gesamtaufnahme - year:2022 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Weiss, Julian J. [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| doi: |
10.1101/2020.09.07.20188813 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XBI018717497 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XBI018717497 | ||
| 003 | DE-627 | ||
| 005 | 20230429085339.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200911s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/2020.09.07.20188813 |2 doi | |
| 035 | |a (DE-627)XBI018717497 | ||
| 035 | |a (biorXiv)10.1101/2020.09.07.20188813 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Weiss, Julian J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Background Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through their contact with vulnerable patients. Smell loss has been associated with SARS-CoV-2 infection, but it is unknown whether monitoring for smell loss can be used to identify asymptomatic infection among high risk individuals, like HCW.Methods We performed a prospective cohort study, tracking 473 HCW across three months to determine if smell loss could predict SARS-CoV-2 infection in this high-risk group. HCW subjects completed a longitudinal, novel behavioral at-home assessment of smell function with household items, as well as detailed symptom surveys that included a parosmia screening questionnaire, and RT-qPCR testing to identify SARSCoV-2 infection.Results SARS-CoV-2 was identified in 17 (3.6%) of 473 HCW. Among the 17 infected HCW, 53% reported smell loss, and were more likely to report smell loss than COVID-negative HCW on both the at-home assessment and the screening questionnaire (P< .01). 67% reported smell loss prior to having a positive SARS-CoV-2 test, and smell loss was reported a median of two days before testing positive. Neurological symptoms were reported more frequently among COVID-positive HCW who reported smell loss (P< .01).Conclusions In this prospective study of HCW, self-reported changes in smell using two different measures were predictive of COVID-19 infection. Smell loss frequently preceded a positive test and was associated with neurological symptoms. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Attuquayefio, Tuki N. |e verfasserin |4 aut | |
| 700 | 1 | |a White, Elizabeth B. |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Fangyong |e verfasserin |4 aut | |
| 700 | 1 | |a Herz, Rachel S. |e verfasserin |4 aut | |
| 700 | 1 | |a White, Theresa L. |e verfasserin |4 aut | |
| 700 | 1 | |a Campbell, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Bertie |e verfasserin |4 aut | |
| 700 | 1 | |a Datta, Rupak |e verfasserin |4 aut | |
| 700 | 1 | |a Wyllie, Anne L. |e verfasserin |4 aut | |
| 700 | 1 | |a Grubaugh, Nathan D. |e verfasserin |4 aut | |
| 700 | 1 | |a Casanovas-Massana, Arnau |e verfasserin |4 aut | |
| 700 | 1 | |a Catherine Muenker, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Handoko, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Iwasaki, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Martinello, Richard A. |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Albert I. |e verfasserin |4 aut | |
| 700 | 1 | |a Small, Dana M. |e verfasserin |4 aut | |
| 700 | 1 | |a Farhadian, Shelli F. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2022) vom: 17. Nov. |
| 773 | 1 | 8 | |g year:2022 |g day:17 |g month:11 |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0248025 |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2020.09.07.20188813 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2022 |b 17 |c 11 | ||