Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
ABSTRACT Altered expression of the complement componentC4Agene is a known risk factor for schizophrenia. Further, predicted brainC4Aexpression has also been associated with memory function highlighting that altered C4A expression in the brain may be relevant for cognitive and behavioral traits. We investigated if predicted brainC4Aexpression was associated with cognitive performance and brain imaging measures in the UK Biobank. We identified significant negative associations between predictedC4Aexpression and performance on select cognitive tests, and significant associations with MRI-based cortical thickness and surface area in select regions. Finally, we observed significant inconsistent partial mediation of the effects of predictedC4Aexpression on cognitive performance, by specific brain structure measures. These results demonstrate that theC4risk locus is associated with the central endophenotypes of cognitive performance and brain morphology, even when considered independently of other genetic risk factors and in individuals without mental or neurological disorders..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 02. Okt. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
O’Connell, Kevin S [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2020.06.05.20122978 |
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| PPN (Katalog-ID): |
XBI018079806 |
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| 520 | |a ABSTRACT Altered expression of the complement componentC4Agene is a known risk factor for schizophrenia. Further, predicted brainC4Aexpression has also been associated with memory function highlighting that altered C4A expression in the brain may be relevant for cognitive and behavioral traits. We investigated if predicted brainC4Aexpression was associated with cognitive performance and brain imaging measures in the UK Biobank. We identified significant negative associations between predictedC4Aexpression and performance on select cognitive tests, and significant associations with MRI-based cortical thickness and surface area in select regions. Finally, we observed significant inconsistent partial mediation of the effects of predictedC4Aexpression on cognitive performance, by specific brain structure measures. These results demonstrate that theC4risk locus is associated with the central endophenotypes of cognitive performance and brain morphology, even when considered independently of other genetic risk factors and in individuals without mental or neurological disorders. | ||
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