Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.One Sentence Summary Broad immune perturbations in severe COVID-19.
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 01. Okt. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2020.05.18.101717 |
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| PPN (Katalog-ID): |
XBI017923778 |
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| 520 | |a Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.One Sentence Summary Broad immune perturbations in severe COVID-19 | ||
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| 700 | 1 | |a Meng, Wenzhao |4 aut | |
| 700 | 1 | |a Rosenfeld, Aaron M. |4 aut | |
| 700 | 1 | |a Ittner, Caroline A.G. |4 aut | |
| 700 | 1 | |a Weisman, Ariel R. |4 aut | |
| 700 | 1 | |a Agyekum, Roseline |4 aut | |
| 700 | 1 | |a Mathew, Divij |4 aut | |
| 700 | 1 | |a Baxter, Amy E. |4 aut | |
| 700 | 1 | |a Vella, Laura |4 aut | |
| 700 | 1 | |a Kuthuru, Oliva |4 aut | |
| 700 | 1 | |a Apostolidis, Sokratis |4 aut | |
| 700 | 1 | |a Bershaw, Luanne |4 aut | |
| 700 | 1 | |a Dougherty, Jeannete |4 aut | |
| 700 | 1 | |a Greenplate, Allison R. |4 aut | |
| 700 | 1 | |a Pattekar, Ajinkya |4 aut | |
| 700 | 1 | |a Kim, Justin |4 aut | |
| 700 | 1 | |a Han, Nicholas |4 aut | |
| 700 | 1 | |a Gouma, Sigrid |0 (orcid)0000-0002-7853-8340 |4 aut | |
| 700 | 1 | |a Weirick, Madison E. |4 aut | |
| 700 | 1 | |a Arevalo, Claudia P. |4 aut | |
| 700 | 1 | |a Bolton, Marcus J. |4 aut | |
| 700 | 1 | |a Goodwin, Eileen C. |4 aut | |
| 700 | 1 | |a Anderson, Elizabeth M. |4 aut | |
| 700 | 1 | |a Hensley, Scott E. |0 (orcid)0000-0002-2928-7506 |4 aut | |
| 700 | 1 | |a Jones, Tiffanie K. |4 aut | |
| 700 | 1 | |a Mangalmurti, Nilam S. |4 aut | |
| 700 | 1 | |a Luning Prak, Eline T. |4 aut | |
| 700 | 1 | |a Wherry, E. John |4 aut | |
| 700 | 1 | |a Meyer, Nuala J. |4 aut | |
| 700 | 1 | |a Betts, Michael R. |4 aut | |
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