Bitter Melon (Momordica Charantia) Supplementation Has no Effect on Hypercholesterolemia and Atherosclerosis in Mice
Abstract Momordica Charantia, commonly known as bitter melon, has been reported to ameliorate diet-induced obesity and dyslipidemia. However, the effects of M. Charantia on atherosclerosis have not been determined. This study investigated the effects of M. Charantia on diet-induced atherosclerosis in LDL receptor deficient mice. Female mice (6-8 weeks old) were fed a saturated fat-enriched diet. In group 1, mice were fed this diet alone, while mice in groups 2 and 3 were fed the diet supplemented with M. Charantia either 0.1% or 1% by weight, for 12 weeks. No significant differences in body weights were observed among the 3 groups. There were also no significant differences in plasma cholesterol concentrations among the 3 groups. To determine the effects on atherosclerosis, lesion areas were measured on aortic intima by an en face technique. Neither dose of M. Charantia supplementation changed atherosclerosis development..
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Preprint| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
bioRxiv.org - (2020) vom: 08. Dez. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mohammadmoradi, Shayan [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2020.04.27.043430 |
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| PPN (Katalog-ID): |
XBI017753201 |
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| 520 | |a Abstract Momordica Charantia, commonly known as bitter melon, has been reported to ameliorate diet-induced obesity and dyslipidemia. However, the effects of M. Charantia on atherosclerosis have not been determined. This study investigated the effects of M. Charantia on diet-induced atherosclerosis in LDL receptor deficient mice. Female mice (6-8 weeks old) were fed a saturated fat-enriched diet. In group 1, mice were fed this diet alone, while mice in groups 2 and 3 were fed the diet supplemented with M. Charantia either 0.1% or 1% by weight, for 12 weeks. No significant differences in body weights were observed among the 3 groups. There were also no significant differences in plasma cholesterol concentrations among the 3 groups. To determine the effects on atherosclerosis, lesion areas were measured on aortic intima by an en face technique. Neither dose of M. Charantia supplementation changed atherosclerosis development. | ||
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