Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load
Abstract We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6-87% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 24. März Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gonçalves, Antonio [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/2020.04.04.20047886 |
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| PPN (Katalog-ID): |
XBI000970727 |
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| 520 | |a Abstract We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6-87% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients. | ||
| 700 | 1 | |a Bertrand, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Ke, Ruian |e verfasserin |4 aut | |
| 700 | 1 | |a Comets, Emmanuelle |e verfasserin |4 aut | |
| 700 | 1 | |a de Lamballerie, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Malvy, Denis |e verfasserin |4 aut | |
| 700 | 1 | |a Pizzorno, Andrés |e verfasserin |4 aut | |
| 700 | 1 | |a Terrier, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Calatrava, Manuel Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Mentré, France |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Perelson, Alan S |e verfasserin |4 aut | |
| 700 | 1 | |a Guedj, Jérémie |e verfasserin |4 aut | |
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