New kinship and<i>F</i><sub>ST</sub>estimates reveal higher levels of differentiation in the global human population
Kinship coefficients andFST, which measure genetic relatedness and the overall population structure, respectively, have important biomedical applications. However, existing estimators are only accurate under restrictive conditions that most natural population structures do not satisfy. We recently derived new kinship andFSTestimators for arbitrary population structures [1, 2]. Our estimates on human datasets reveal a complex population structure driven by founder effects due to dispersal from Africa and admixture. Notably, our new approach estimates largerFSTvalues of 26% for native worldwide human populations and 23% for admixed Hispanic individuals, whereas the existing approach estimates 9.8% and 2.6%, respectively. While previous work correctly measuredFSTbetween subpopulation pairs, our generalizedFSTmeasures genetic distances among all individuals and their most recent common ancestor (MRCA) population, revealing that genetic differentiation is greater than previously appreciated. This analysis demonstrates that estimating kinship andFSTunder more realistic assumptions is important for modern population genetic analysis..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 18. Sept. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ochoa, Alejandro [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/653279 |
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| PPN (Katalog-ID): |
XBI000530867 |
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| 245 | 1 | 0 | |a New kinship and<i>F</i><sub>ST</sub>estimates reveal higher levels of differentiation in the global human population |
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| 520 | |a Kinship coefficients andFST, which measure genetic relatedness and the overall population structure, respectively, have important biomedical applications. However, existing estimators are only accurate under restrictive conditions that most natural population structures do not satisfy. We recently derived new kinship andFSTestimators for arbitrary population structures [1, 2]. Our estimates on human datasets reveal a complex population structure driven by founder effects due to dispersal from Africa and admixture. Notably, our new approach estimates largerFSTvalues of 26% for native worldwide human populations and 23% for admixed Hispanic individuals, whereas the existing approach estimates 9.8% and 2.6%, respectively. While previous work correctly measuredFSTbetween subpopulation pairs, our generalizedFSTmeasures genetic distances among all individuals and their most recent common ancestor (MRCA) population, revealing that genetic differentiation is greater than previously appreciated. This analysis demonstrates that estimating kinship andFSTunder more realistic assumptions is important for modern population genetic analysis. | ||
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