Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity
Abstract A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Among these 12 compounds the three compounds6c,7band7dshowed good anti-oxidant activity and the compound6cattenuataed LDL oxidation by 32%. The compounds6cand7dalso showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for anti-adipogenic and anti-hyperglycemic activity, where6cwas found most active compound with 44% reduction in lipid accumulation and 20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug metformin..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
bioRxiv.org - (2022) vom: 06. Sept. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Varshney, Kanika [VerfasserIn] |
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| doi: |
10.1101/477315 |
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| PPN (Katalog-ID): |
XBI000397458 |
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| 520 | |a Abstract A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Among these 12 compounds the three compounds6c,7band7dshowed good anti-oxidant activity and the compound6cattenuataed LDL oxidation by 32%. The compounds6cand7dalso showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for anti-adipogenic and anti-hyperglycemic activity, where6cwas found most active compound with 44% reduction in lipid accumulation and 20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug metformin. | ||
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| 700 | 1 | |a Gupta, Amit K. |e verfasserin |4 aut | |
| 700 | 1 | |a Sonkar, Ravi |e verfasserin |4 aut | |
| 700 | 1 | |a Varshney, Salil |e verfasserin |4 aut | |
| 700 | 1 | |a Mishra, Akanksha |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatia, Geetika |e verfasserin |4 aut | |
| 700 | 1 | |a Gaikwad, Anil |e verfasserin |4 aut | |
| 700 | 1 | |a Srivastava, Arvind Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Saxena, Mridula |e verfasserin |4 aut | |
| 700 | 1 | |a Jain, Sudha |e verfasserin |4 aut | |
| 700 | 1 | |a K.Saxena, Anil |e verfasserin |4 aut | |
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