Effects of exclusive breastfeeding on infant gut microbiota: a meta-analysis across studies and populations
Abstract Literature regarding the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants is meager with large variation in methods and results. We performed a meta-analysis of seven studies (a total of 1825 stool samples from 684 infants) to investigate effects of EBF compared to non-EBF on infant gut microbiota across different populations. In the first 6 months of life, overall bacterial diversity, gut microbiota age, relative abundances of Bacteroidetes and Firmicutes and microbial-predicted pathways related to carbohydrate metabolism were consistently increased; while relative abundances of pathways related to lipid, vitamin metabolism and detoxification were decreased in non-EBF vs. EBF infants. The perturbation in microbial-predicted pathways associated with non-EBF was larger in infants delivered by C-section than delivered vaginally. Longer duration of EBF mitigated diarrhea-associated gut microbiota dysbiosis and the effects of EBF persisted after 6 months of age. These consistent findings across vastly different populations suggest that one of the mechanisms of short and long-term benefits of EBF may be alteration in gut microbes..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
bioRxiv.org - (2021) vom: 15. Dez. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ho, Nhan T. [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/292755 |
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| PPN (Katalog-ID): |
XBI000257443 |
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| 520 | |a Abstract Literature regarding the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants is meager with large variation in methods and results. We performed a meta-analysis of seven studies (a total of 1825 stool samples from 684 infants) to investigate effects of EBF compared to non-EBF on infant gut microbiota across different populations. In the first 6 months of life, overall bacterial diversity, gut microbiota age, relative abundances of Bacteroidetes and Firmicutes and microbial-predicted pathways related to carbohydrate metabolism were consistently increased; while relative abundances of pathways related to lipid, vitamin metabolism and detoxification were decreased in non-EBF vs. EBF infants. The perturbation in microbial-predicted pathways associated with non-EBF was larger in infants delivered by C-section than delivered vaginally. Longer duration of EBF mitigated diarrhea-associated gut microbiota dysbiosis and the effects of EBF persisted after 6 months of age. These consistent findings across vastly different populations suggest that one of the mechanisms of short and long-term benefits of EBF may be alteration in gut microbes. | ||
| 700 | 1 | |a Li, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee-Sarwar, Kathleen A. |e verfasserin |4 aut | |
| 700 | 1 | |a Tun, Hein M. |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Bryan |e verfasserin |4 aut | |
| 700 | 1 | |a Pannaraj, Pia S. |e verfasserin |4 aut | |
| 700 | 1 | |a Bender, Jeffrey M. |e verfasserin |4 aut | |
| 700 | 1 | |a Azad, Meghan B. |e verfasserin |4 aut | |
| 700 | 1 | |a Thompson, Amanda L. |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Scott T. |e verfasserin |4 aut | |
| 700 | 1 | |a Azcarate-Peril, M. Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Litonjua, Augusto A. |e verfasserin |4 aut | |
| 700 | 1 | |a Kozyrskyj, Anita L. |e verfasserin |4 aut | |
| 700 | 1 | |a Jaspan, Heather B. |e verfasserin |4 aut | |
| 700 | 1 | |a Aldrovandi, Grace M. |e verfasserin |4 aut | |
| 700 | 1 | |a Kuhn, Louise |e verfasserin |4 aut | |
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