Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection
Abstract The pool of memory-phenotype CD8 T cells is composed of antigen-induced (AI) and cytokine-induced innate (IN) cells. IN have been described as having similar properties to AI memory cells. However, we found that pathogen-induced AI memory cells can be distinguished from naturally-generated IN memory cells by surface expression of NKG2D. Using this marker, we described the increased functionalities of AI and IN memory CD8 T cells compared to naive cells, as shown by comprehensive analysis of cytokine secretion and gene expression. However, AI differed from IN memory CD8 T cells by their capacity to migrate to the lung parenchyma upon inflammation or infection, a process dependent on their expression of ITGA1/CD49a and ITGA4/CD49d integrins..
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Preprint| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
bioRxiv.org - (2020) vom: 18. Jan. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grau, Morgan [VerfasserIn] |
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| Links: |
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| doi: |
10.1101/224782 |
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| PPN (Katalog-ID): |
XBI000206105 |
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| 245 | 1 | 0 | |a Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection |
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| 520 | |a Abstract The pool of memory-phenotype CD8 T cells is composed of antigen-induced (AI) and cytokine-induced innate (IN) cells. IN have been described as having similar properties to AI memory cells. However, we found that pathogen-induced AI memory cells can be distinguished from naturally-generated IN memory cells by surface expression of NKG2D. Using this marker, we described the increased functionalities of AI and IN memory CD8 T cells compared to naive cells, as shown by comprehensive analysis of cytokine secretion and gene expression. However, AI differed from IN memory CD8 T cells by their capacity to migrate to the lung parenchyma upon inflammation or infection, a process dependent on their expression of ITGA1/CD49a and ITGA4/CD49d integrins. | ||
| 700 | 1 | |a Valsesia, Séverine |e verfasserin |4 aut | |
| 700 | 1 | |a Mafille, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Djebali, Sophia |e verfasserin |4 aut | |
| 700 | 1 | |a Tomkowiak, Martine |e verfasserin |4 aut | |
| 700 | 1 | |a Mathieu, Anne-Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Laubreton, Daphné |e verfasserin |4 aut | |
| 700 | 1 | |a de Bernard, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Jouve, Pierre-Emmanuel |e verfasserin |4 aut | |
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| 700 | 1 | |a Walzer, Thierry |e verfasserin |4 aut | |
| 700 | 1 | |a Leverrier, Yann |e verfasserin |4 aut | |
| 700 | 1 | |a Marvel, Jacqueline |e verfasserin |4 aut | |
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