Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics
The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat the pandemic. Mechanistic viral dynamics and quantitative systems pharmacology models of SARS-CoV-2 infection, vaccines, immunomodulatory agents, and antiviral therapeutics have played a key role in advancing our understanding of SARS-CoV-2 pathogenesis and transmission, the interplay between innate and adaptive immunity to influence the outcomes of infection, effectiveness of treatments, mechanisms and performance of COVID-19 vaccines, and the impact of emerging SARS-CoV-2 variants. Here, we review some of the critical insights provided by these models and discuss the challenges ahead..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
arXiv.org - (2021) vom: 17. Dez. Zur Gesamtaufnahme - year:2021 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Desikan, Rajat [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
XAR033265658 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XAR033265658 | ||
| 003 | DE-627 | ||
| 005 | 20230429070447.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211221s2021 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)XAR033265658 | ||
| 035 | |a (arXiv)2112.10500 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 570 |q DE-84 | |
| 100 | 1 | |a Desikan, Rajat |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat the pandemic. Mechanistic viral dynamics and quantitative systems pharmacology models of SARS-CoV-2 infection, vaccines, immunomodulatory agents, and antiviral therapeutics have played a key role in advancing our understanding of SARS-CoV-2 pathogenesis and transmission, the interplay between innate and adaptive immunity to influence the outcomes of infection, effectiveness of treatments, mechanisms and performance of COVID-19 vaccines, and the impact of emerging SARS-CoV-2 variants. Here, we review some of the critical insights provided by these models and discuss the challenges ahead. | ||
| 700 | 1 | |a Padmanabhan, Pranesh |e verfasserin |4 aut | |
| 700 | 1 | |a Kierzek, Andrzej M. |e verfasserin |4 aut | |
| 700 | 1 | |a van der Graaf, Piet H. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t arXiv.org |g (2021) vom: 17. Dez. |
| 773 | 1 | 8 | |g year:2021 |g day:17 |g month:12 |
| 856 | 4 | 0 | |u https://arxiv.org/abs/2112.10500 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XAR | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2021 |b 17 |c 12 | ||
| 953 | |2 045F |a 570 | ||