Cooperativity transitions driven by higher-order oligomer formations in ligand-induced receptor dimerization
While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer (e.g., trimer and tetramer) formations of unobserved receptors have received less attention. Here, we propose a dimerization model of ligand-induced receptors in multivalent form representing physical observables under basis vectors of various aggregated receptor-states. Our simulations of multivalent models not only reject Wofsy-Goldstein parameter conditions for cooperativity, but show higher-order oligomer formations can shift cooperativity from positive to negative..
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Preprint| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
arXiv.org - (2019) vom: 27. Mai Zur Gesamtaufnahme - year:2019 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Watabe, Masaki [VerfasserIn] |
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| Links: |
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| doi: |
10.1103/PhysRevE.100.062407 |
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| PPN (Katalog-ID): |
XAR010026630 |
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| 520 | |a While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer (e.g., trimer and tetramer) formations of unobserved receptors have received less attention. Here, we propose a dimerization model of ligand-induced receptors in multivalent form representing physical observables under basis vectors of various aggregated receptor-states. Our simulations of multivalent models not only reject Wofsy-Goldstein parameter conditions for cooperativity, but show higher-order oligomer formations can shift cooperativity from positive to negative. | ||
| 700 | 1 | |a Watabe, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Arjunan, Satya N. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Chew, Wei Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Kaizu, Kazunari |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Koichi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t arXiv.org |g (2019) vom: 27. Mai |
| 773 | 1 | 8 | |g year:2019 |g day:27 |g month:05 |
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