Synthesis and Characterization of Spirooxindoleβ‐Ketothiolester and their Fluorescence Imaging on PC3 Cells
Abstract Biologically‐active near‐ultraviolet emitting spirooxindole‐pyrrolidine/pyrrolothiazole‐β‐ketothiolester have been synthesised via Chemo‐/regio‐/stereoselective manner. Excited‐state intramolecular proton transfer (ESIPT) of β‐ketothiolester exhibits excitation‐dependent emission with intermolecular hydrogen bonding ability with solvents. The emission could be tunable between 330 nm to 460 nm. Selected fluorescent compounds 4{4,2,1}, 4{12,2,2}, 5{4,2,1} and 5{12,2,2} shows cytotoxicity effect on PC3 cells, where the highest IC50 value (6 μM) was found for the probe 5{12,2,2}. The fluorescent behavior of 5{4,2,1} and 5{12,2,2} acted as an imaging molecule against cancer cells..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
ChemistrySelect - 9(2024), 10 |
| Beteiligte Personen: |
Sriram Babu, Seenivasagaperumal [VerfasserIn] |
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| Anmerkungen: |
© 2024 Wiley‐VCH GmbH |
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| Umfang: |
10 |
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| doi: |
10.1002/slct.202303884 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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WLY018233864 |
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| 520 | |a Abstract Biologically‐active near‐ultraviolet emitting spirooxindole‐pyrrolidine/pyrrolothiazole‐β‐ketothiolester have been synthesised via Chemo‐/regio‐/stereoselective manner. Excited‐state intramolecular proton transfer (ESIPT) of β‐ketothiolester exhibits excitation‐dependent emission with intermolecular hydrogen bonding ability with solvents. The emission could be tunable between 330 nm to 460 nm. Selected fluorescent compounds 4{4,2,1}, 4{12,2,2}, 5{4,2,1} and 5{12,2,2} shows cytotoxicity effect on PC3 cells, where the highest IC50 value (6 μM) was found for the probe 5{12,2,2}. The fluorescent behavior of 5{4,2,1} and 5{12,2,2} acted as an imaging molecule against cancer cells. | ||
| 700 | 1 | |a Savitha Devi, Natarajan |4 aut | |
| 700 | 1 | |a Manjula Devi, Ramamoorthy |4 aut | |
| 700 | 1 | |a Dhiraviam Kannan, Narayanan |4 aut | |
| 700 | 1 | |a Sivakumar, Shanmugam |4 aut | |
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