Metal‐Free, Hindered, Regioselective Access to Multifunctional Groups Diarylamines via S N Ar Substitution of P‐Nitroso Aromatic Methyl Ether by Arylamines
Abstract Multifunctional groups diarylamines, an innovative product, efficiently produced from arylamines and p‐nitrosoanisole derivatives by intermolecular S N Ar under weak acid conditions. This S N Ar proceeds under mild reaction conditions, and more significantly, the substrates involved do not necessarily require strong electron‐withdrawing groups. Moreover, this S N Ar is characterized by resistance to space crowding, tolerance to halogen and nitroso functional groups, and high regioselectivity. Mechanistic observations suggest that the S N Ar is the result of the transfer of the positive charge center of the protonated nitroso group to the p‐methoxy group..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Chemistry – A European Journal - 30(2024), 11 |
| Beteiligte Personen: |
Zou, Shuliang [VerfasserIn] |
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| Anmerkungen: |
© 2024 Wiley‐VCH GmbH |
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| Umfang: |
6 |
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| doi: |
10.1002/chem.202303421 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
WLY017372658 |
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| 245 | 1 | 0 | |a Metal‐Free, Hindered, Regioselective Access to Multifunctional Groups Diarylamines via S N Ar Substitution of P‐Nitroso Aromatic Methyl Ether by Arylamines |
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| 520 | |a Abstract Multifunctional groups diarylamines, an innovative product, efficiently produced from arylamines and p‐nitrosoanisole derivatives by intermolecular S N Ar under weak acid conditions. This S N Ar proceeds under mild reaction conditions, and more significantly, the substrates involved do not necessarily require strong electron‐withdrawing groups. Moreover, this S N Ar is characterized by resistance to space crowding, tolerance to halogen and nitroso functional groups, and high regioselectivity. Mechanistic observations suggest that the S N Ar is the result of the transfer of the positive charge center of the protonated nitroso group to the p‐methoxy group. | ||
| 700 | 1 | |a Zhang, Yazhou |4 aut | |
| 700 | 1 | |a Wu, Qin |4 aut | |
| 700 | 1 | |a Zhao, Tianming |4 aut | |
| 700 | 1 | |a Li, Yutao |4 aut | |
| 700 | 1 | |a Liu, Bing |4 aut | |
| 700 | 1 | |a Ma, Xianguo |4 aut | |
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