Thrombosis risk with haemoglobin C trait and haemoglobin C disease : A systematic review
Summary The thrombotic risk with haemoglobin C trait (HbAC) or haemoglobin C disease (HbCC) is unclear. However, individuals with HbCC have demonstrated chronic haemolysis, higher blood viscosity and altered rheology when compared to individuals with wild‐type haemoglobin (HbAA). These physiological alterations may theoretically translate to increased risk of thrombosis; therefore, a systematic literature review was performed to investigate the possible association between HbAC and/or HbCC and thrombosis. Twenty‐two studies met inclusion criteria representing 782 individuals with HbAC ( n = 694) or HbCC ( n = 88). Fifteen studies described the presence/absence of venous thromboembolism (VTE) in patients with HbAC ( n = 685) or HbCC ( n = 79), while seven studies described patients with HbAC ( n = 9) or HbCC ( n = 9) and arterial thrombosis. Most ( n = 20) studies were case reports or case series; however, two studies suggested a potential increased VTE risk with HbAC compared to HbAA in (i) all patients (OR 2.2, 95% CI: 0.9–5.5) and in (ii) pregnant individuals (RR 3.7, 95% CI 0.9–16). This review is the largest assessment of patients with HbC trait or disease and thrombosis to date; despite its limitations, the findings suggest HbC may be a predisposing risk factor to thrombosis. Prospective cohort studies are warranted to definitively elucidate the risk of thrombosis in this population..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:204 |
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| Enthalten in: |
British Journal of Haematology - 204(2024), 4, Seite 1500-1506 |
| Beteiligte Personen: |
Jacobs, Jeremy W. [VerfasserIn] |
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| Anmerkungen: |
© 2024 British Society for Haematology and John Wiley & Sons Ltd. |
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| Umfang: |
7 |
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| doi: |
10.1111/bjh.19313 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
WLY017282128 |
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| 100 | 1 | |a Jacobs, Jeremy W. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Thrombosis risk with haemoglobin C trait and haemoglobin C disease |b A systematic review |
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| 520 | |a Summary The thrombotic risk with haemoglobin C trait (HbAC) or haemoglobin C disease (HbCC) is unclear. However, individuals with HbCC have demonstrated chronic haemolysis, higher blood viscosity and altered rheology when compared to individuals with wild‐type haemoglobin (HbAA). These physiological alterations may theoretically translate to increased risk of thrombosis; therefore, a systematic literature review was performed to investigate the possible association between HbAC and/or HbCC and thrombosis. Twenty‐two studies met inclusion criteria representing 782 individuals with HbAC ( n = 694) or HbCC ( n = 88). Fifteen studies described the presence/absence of venous thromboembolism (VTE) in patients with HbAC ( n = 685) or HbCC ( n = 79), while seven studies described patients with HbAC ( n = 9) or HbCC ( n = 9) and arterial thrombosis. Most ( n = 20) studies were case reports or case series; however, two studies suggested a potential increased VTE risk with HbAC compared to HbAA in (i) all patients (OR 2.2, 95% CI: 0.9–5.5) and in (ii) pregnant individuals (RR 3.7, 95% CI 0.9–16). This review is the largest assessment of patients with HbC trait or disease and thrombosis to date; despite its limitations, the findings suggest HbC may be a predisposing risk factor to thrombosis. Prospective cohort studies are warranted to definitively elucidate the risk of thrombosis in this population. | ||
| 700 | 1 | |a Sharma, Deva |4 aut | |
| 700 | 1 | |a Stephens, Laura D. |4 aut | |
| 700 | 1 | |a Figueroa Villalba, Cristina A. |4 aut | |
| 700 | 1 | |a Rinder, Henry M. |4 aut | |
| 700 | 1 | |a Woo, Jennifer S. |4 aut | |
| 700 | 1 | |a Wheeler, Allison P. |4 aut | |
| 700 | 1 | |a Gerberi, Dana |4 aut | |
| 700 | 1 | |a Goel, Ruchika |4 aut | |
| 700 | 1 | |a Tormey, Christopher A. |4 aut | |
| 700 | 1 | |a Booth, Garrett S. |4 aut | |
| 700 | 1 | |a Bloch, Evan M. |4 aut | |
| 700 | 1 | |a Adkins, Brian D. |4 aut | |
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