Inflammatory markers in pregnant women with periodontal diseases—Systematic review and network meta‐analysis
Abstract Periodontal diseases (PD) have been associated with adverse pregnancy outcomes. Several studies reported on cytokines concentrations and oxidative stress in periodontal patients during pregnancy. We aimed at reviewing systemic inflammatory markers concentrations and oxidative stress status in the serum of pregnant women with periodontal diseases (PD) and gestational diabetes mellitus (GDM). In this systematic review and network meta‐analysis, 5595 studies were screened. In the non‐GDM arm of 48 reviewed articles, 11 were included: six for CRP, two for TNF‐alpha, and three for total antioxidant capacity (TAOC). CRP and TNF‐alpha were higher in PD groups in comparison with healthy periodontum group; however, the differences were not statistically significant, whereas TAOC was lower in PD group. In the GDM arm of eight articles, two were included: one for CRP and one for adiponectin and leptin, which was insufficient for further analysis. The evidence for differences in the concentrations of inflammatory markers in pregnant women with PD and with healthy periodontum is limited, mainly due to confounding factors such as varying PD diagnostic criteria and methodology of assessing cytokine levels. However, these results may suggest a particular trend toward an attenuated inflammatory response in pregnant periodontal patients. There still exists a paucity of data on the subject..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Oral Science International - 20(2023), 2, Seite 67-77 |
| Beteiligte Personen: |
Kania, Michal [VerfasserIn] |
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| Anmerkungen: |
© 2023 Japanese Stomatological Society |
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| Umfang: |
11 |
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| doi: |
10.1002/osi2.1154 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Periodontal diseases (PD) have been associated with adverse pregnancy outcomes. Several studies reported on cytokines concentrations and oxidative stress in periodontal patients during pregnancy. We aimed at reviewing systemic inflammatory markers concentrations and oxidative stress status in the serum of pregnant women with periodontal diseases (PD) and gestational diabetes mellitus (GDM). In this systematic review and network meta‐analysis, 5595 studies were screened. In the non‐GDM arm of 48 reviewed articles, 11 were included: six for CRP, two for TNF‐alpha, and three for total antioxidant capacity (TAOC). CRP and TNF‐alpha were higher in PD groups in comparison with healthy periodontum group; however, the differences were not statistically significant, whereas TAOC was lower in PD group. In the GDM arm of eight articles, two were included: one for CRP and one for adiponectin and leptin, which was insufficient for further analysis. The evidence for differences in the concentrations of inflammatory markers in pregnant women with PD and with healthy periodontum is limited, mainly due to confounding factors such as varying PD diagnostic criteria and methodology of assessing cytokine levels. However, these results may suggest a particular trend toward an attenuated inflammatory response in pregnant periodontal patients. There still exists a paucity of data on the subject. | ||
| 700 | 1 | |a Malinowski, Krzysztof Piotr |4 aut | |
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| 700 | 1 | |a Szopa, Magdalena |4 aut | |
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