Infection metallomics for critical care in the post‐COVID era

Abstract Infection metallomics is a mass spectrometry (MS) platform we established based on the central concept that microbial metallophores are specific, sensitive, noninvasive, and promising biomarkers of invasive infectious diseases. Here we review the in vitro, in vivo, and clinical applications of metallophores from historical and functional perspectives, and identify under‐studied and emerging application areas with high diagnostic potential for the post‐COVID era. MS with isotope data filtering is fundamental to infection metallomics; it has been used to study the interplay between “frenemies” in hosts and to monitor the dynamic response of the microbiome to antibiotic and antimycotic therapies. During infection in critically ill patients, the hostile environment of the host's body activates secondary bacterial, mycobacterial, and fungal metabolism, leading to the production of metallophores that increase the pathogen's chance of survival in the host. MS can reveal the structures, stability, and threshold concentrations of these metal‐containing microbial biomarkers of infection in humans and model organisms, and can discriminate invasive disease from benign colonization based on well‐defined thresholds distinguishing proliferation from the colonization steady state..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:42
Enthalten in:	Mass Spectrometry Reviews - 42(2023), 4, Seite 1221-1243

Beteiligte Personen:	Patil, Rutuja H. [VerfasserIn] Luptáková, Dominika [VerfasserIn] Havlíček, Vladimír [VerfasserIn]

Anmerkungen:	© 2023 John Wiley & Sons Ltd.

Umfang:	23

doi:	10.1002/mas.21755

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	WLY016363353