Myoclonus in patients with COVID‐19 : Findings of autoantibodies against brain structures in cerebrospinal fluid
Abstract Background and purpose COVID‐19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID‐19 infection, with no previous neurological disease, are decsribed. Metods Analysis of cerebrospinal fluid from the cases using indirect immunohistochemistry. Results Antibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus. Conclusion Our results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID‐19 associated myoclonus..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
European Journal of Neurology - 30(2023), 10, Seite 3142-3148 |
| Beteiligte Personen: |
Lindqvist, Isa [VerfasserIn] |
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| Anmerkungen: |
Copyright © 2023 European Academy of Neurology |
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| Umfang: |
7 |
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| doi: |
10.1111/ene.15958 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
WLY015625664 |
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| 245 | 1 | 0 | |a Myoclonus in patients with COVID‐19 |b Findings of autoantibodies against brain structures in cerebrospinal fluid |
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| 520 | |a Abstract Background and purpose COVID‐19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID‐19 infection, with no previous neurological disease, are decsribed. Metods Analysis of cerebrospinal fluid from the cases using indirect immunohistochemistry. Results Antibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus. Conclusion Our results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID‐19 associated myoclonus. | ||
| 700 | 1 | |a Cunningham, Janet L. |4 aut | |
| 700 | 1 | |a Mulder, Jan |4 aut | |
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| 700 | 1 | |a Kumlien, Eva |4 aut | |
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