Rhodium‐Catalyzed Dearomative 1,4‐Acyl Rearrangement of 2‐Oxypyridines with Hydrazones : Access to N‐Substituted 2‐Pyridones
Abstract A rhodium‐catalyzed dearomative 1,4‐acyl migratory rearrangement reaction of 2‐oxypyridines has been developed for the direct synthesis of 2‐alkylated pyridones under mild reaction conditions. Different with the former reports, in this protocol, readily accessible and bench stable vinyl N‐nosylhydrazones instead of diazoacetates have been used as carbene precursors. As a result, a range of N‐alkylated pyridones have been prepared in acceptable yields with good functional group tolerance..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
European Journal of Organic Chemistry - 26(2023), 27 |
| Beteiligte Personen: |
Ni, Yifeng [VerfasserIn] |
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| Anmerkungen: |
© 2023 Wiley‐VCH GmbH |
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| Umfang: |
4 |
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| doi: |
10.1002/ejoc.202300368 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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WLY015544176 |
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| 520 | |a Abstract A rhodium‐catalyzed dearomative 1,4‐acyl migratory rearrangement reaction of 2‐oxypyridines has been developed for the direct synthesis of 2‐alkylated pyridones under mild reaction conditions. Different with the former reports, in this protocol, readily accessible and bench stable vinyl N‐nosylhydrazones instead of diazoacetates have been used as carbene precursors. As a result, a range of N‐alkylated pyridones have been prepared in acceptable yields with good functional group tolerance. | ||
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