Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient
Abstract A 20‐year‐old male presented 3.5 years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was consistent with inflammation and/or demyelination. Lumbar puncture was initially non‐diagnostic and a broad infectious workup was unrevealing. Three months after presentation, a repeat LP detected JC virus for which tests had not earlier been conducted. He continued to deteriorate despite withdrawal of prior immunosuppression and addition of mirtazapine, maraviroc, and steroids. He died of progressive neurologic decompensation 5 months after his initial presentation. This case highlights progressive multifocal leukoencephalopathy (PML) as a rare complication after solid organ transplantation and acute sensorineural hearing loss as an unusual first presenting symptom of PML. JC virus should be considered in the differential diagnosis of acute sensorineural hearing loss in any immunocompromised patient..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Transplant Infectious Disease - 22(2020), 4 |
| Beteiligte Personen: |
Lippa, Andrew M. [VerfasserIn] |
|---|
| BKL: |
|---|
| Anmerkungen: |
© 2020 Wiley Periodicals, Inc. |
|---|
| Umfang: |
8 |
|---|
| doi: |
10.1111/tid.13304 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
WLY013858734 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | WLY013858734 | ||
| 003 | DE-627 | ||
| 005 | 20230308022748.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230221s2020 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1111/tid.13304 |2 doi | |
| 028 | 5 | 2 | |a TID_TID13304.xml |
| 035 | |a (DE-627)WLY013858734 | ||
| 035 | |a (WILEY)TID13304 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 084 | |a 44.65 |2 bkl | ||
| 084 | |a 44.75 |2 bkl | ||
| 100 | 1 | |a Lippa, Andrew M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient |
| 264 | 1 | |c 2020 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © 2020 Wiley Periodicals, Inc. | ||
| 520 | |a Abstract A 20‐year‐old male presented 3.5 years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was consistent with inflammation and/or demyelination. Lumbar puncture was initially non‐diagnostic and a broad infectious workup was unrevealing. Three months after presentation, a repeat LP detected JC virus for which tests had not earlier been conducted. He continued to deteriorate despite withdrawal of prior immunosuppression and addition of mirtazapine, maraviroc, and steroids. He died of progressive neurologic decompensation 5 months after his initial presentation. This case highlights progressive multifocal leukoencephalopathy (PML) as a rare complication after solid organ transplantation and acute sensorineural hearing loss as an unusual first presenting symptom of PML. JC virus should be considered in the differential diagnosis of acute sensorineural hearing loss in any immunocompromised patient. | ||
| 700 | 1 | |a Ocwieja, Karen E. |4 aut | |
| 700 | 1 | |a Iglesias, Julie |4 aut | |
| 700 | 1 | |a Fawaz, Rima |4 aut | |
| 700 | 1 | |a Elisofon, Scott |4 aut | |
| 700 | 1 | |a Lee, Christine |4 aut | |
| 700 | 1 | |a Sharma, Tanvi S. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transplant Infectious Disease |g 22(2020), 4 |w (DE-627)WLY013856561 |x 13993062 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2020 |g number:4 |g extent:8 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_WLY | ||
| 936 | b | k | |a 44.65 |q ASE |
| 936 | b | k | |a 44.75 |q ASE |
| 951 | |a AR | ||
| 952 | |d 22 |j 2020 |e 4 |g 8 | ||