Facile and Efficient Nitration of 4‐Aryl‐1(2H)‐Phthalazinone Derivatives Using Different Catalysts
Abstract Different nitration methods were investigated on 4‐(4‐mthoxy‐3‐methyl phenyl)‐1(2H)‐phthalazinone and its derivatives using HNO3 as a nitrating agent with different catalysts. LC–MS/MS has been used to determine the product‘s structure. The results showed that the most suitable catalyst was P2 O5 at room temperature to introduce an ortho mono‐nitrated group for the phthalazinone derivatives bearing donating groups on the phenyl ring. In contrast, 4‐halophenyl phthalazinone derivatives gave a high yield of mono‐nitrated products using H2 SO4 as a catalyst. All mono‐nitrated products were separated with good to excellent yields, and their structures were confirmed by FT‐IR, NMR, LC‐MS/MS and elemental analyses..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
ChemistrySelect - 6(2021), 41, Seite 11231-11236 |
| Beteiligte Personen: |
Abdullah, Rokaia Safwat [VerfasserIn] |
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| Anmerkungen: |
© 2021 Wiley‐VCH GmbH |
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| Umfang: |
6 |
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| doi: |
10.1002/slct.202102057 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Different nitration methods were investigated on 4‐(4‐mthoxy‐3‐methyl phenyl)‐1(2H)‐phthalazinone and its derivatives using HNO3 as a nitrating agent with different catalysts. LC–MS/MS has been used to determine the product‘s structure. The results showed that the most suitable catalyst was P2 O5 at room temperature to introduce an ortho mono‐nitrated group for the phthalazinone derivatives bearing donating groups on the phenyl ring. In contrast, 4‐halophenyl phthalazinone derivatives gave a high yield of mono‐nitrated products using H2 SO4 as a catalyst. All mono‐nitrated products were separated with good to excellent yields, and their structures were confirmed by FT‐IR, NMR, LC‐MS/MS and elemental analyses. | ||
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