Atom‐economical Approaches to 1,5‐Benzodiazepines Containing Indole Ring via Fe3 O4SiO2‐PTSA‐catalyzed Multi‐component Domino Reactions
Abstract Four novel atom‐economical approaches for synthesis of 1,5‐dihydrospiro[benzo[ b][1,4]diazepine‐2,3′‐indole] compounds via three‐component or four‐component domino reactions have been developed in the presence of a catalytic amount of magnetic nanoparticles (Fe3 O4SiO2‐PTSA) in ethanol, which provide an efficient one‐pot synthesis of 1,5‐benzodiazepines with multi‐ring system and functional groups containing indole, aryl, ester, acyl and alkyl groups in excellent yields. In a one‐pot operation, two new nitrogen heterocycle (indole and diazepine) rings and four new chemical bonds (one C−C, two C−N and one C=C) were constructed by series of domino reactions. Furthermore, plausible catalytic synthesis reaction mechanisms have been proposed. The advantages of these methods are the green reaction process, the recyclable magnetic catalyst, mild reaction conditions, short reaction time and high yields of products..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
ChemistrySelect - 5(2020), 44, Seite 14056-14061 |
| Beteiligte Personen: |
Zhang, KaiYue [VerfasserIn] |
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| Anmerkungen: |
© 2020 Wiley‐VCH GmbH |
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| Umfang: |
6 |
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| doi: |
10.1002/slct.202003903 |
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| funding: |
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| 520 | |a Abstract Four novel atom‐economical approaches for synthesis of 1,5‐dihydrospiro[benzo[ b][1,4]diazepine‐2,3′‐indole] compounds via three‐component or four‐component domino reactions have been developed in the presence of a catalytic amount of magnetic nanoparticles (Fe3 O4SiO2‐PTSA) in ethanol, which provide an efficient one‐pot synthesis of 1,5‐benzodiazepines with multi‐ring system and functional groups containing indole, aryl, ester, acyl and alkyl groups in excellent yields. In a one‐pot operation, two new nitrogen heterocycle (indole and diazepine) rings and four new chemical bonds (one C−C, two C−N and one C=C) were constructed by series of domino reactions. Furthermore, plausible catalytic synthesis reaction mechanisms have been proposed. The advantages of these methods are the green reaction process, the recyclable magnetic catalyst, mild reaction conditions, short reaction time and high yields of products. | ||
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| 700 | 1 | |a Wang, LanZhi |4 aut | |
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