Ultrasound findings and detection of fetal abnormalities before 11 weeks of gestation
Abstract Objective To determine the proportion of major fetal structural abnormalities that can be detected before 11 gestational weeks. Methods We conducted a retrospective study of individual patient files at a tertiary provider of obstetric and gynecological ultrasound in Melbourne, Australia. All women who had a pre‐cell‐free DNA ultrasound with a crown‐rump length of less than 45 mm and had one or more ultrasounds at a later gestation were included in the analysis. The primary outcome was the incidence of a fetal structural abnormality. Results A total of 3333 cases were included in the final analysis. Overall, 316 fetuses (9.5%) had a structural abnormality detected at any point throughout gestation, of which 86 were major structural abnormalities (2.6%). Sixteen fetal abnormalities were detected before 11 weeks of gestation, including 15 major abnormalities (17.4% of the major anomalies). All major fetal abnormalities detected before 11 gestational weeks were confirmed at later ultrasound examinations or the pregnancy did not continue (in four cases due to termination of pregnancy and in one case spontaneous miscarriage before first trimester morphology ultrasound). Conclusion Detection of fetal abnormalities is possible before 11 weeks of gestation. Early suspicion is more likely in cases of major structural abnormalities..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Prenatal Diagnosis - 41(2021), 13, Seite 1675-1684 |
| Beteiligte Personen: |
Brown, Imogen [VerfasserIn] |
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| BKL: |
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| Anmerkungen: |
© 2021 John Wiley & Sons Ltd. |
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| Umfang: |
10 |
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| doi: |
10.1002/pd.6055 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Objective To determine the proportion of major fetal structural abnormalities that can be detected before 11 gestational weeks. Methods We conducted a retrospective study of individual patient files at a tertiary provider of obstetric and gynecological ultrasound in Melbourne, Australia. All women who had a pre‐cell‐free DNA ultrasound with a crown‐rump length of less than 45 mm and had one or more ultrasounds at a later gestation were included in the analysis. The primary outcome was the incidence of a fetal structural abnormality. Results A total of 3333 cases were included in the final analysis. Overall, 316 fetuses (9.5%) had a structural abnormality detected at any point throughout gestation, of which 86 were major structural abnormalities (2.6%). Sixteen fetal abnormalities were detected before 11 weeks of gestation, including 15 major abnormalities (17.4% of the major anomalies). All major fetal abnormalities detected before 11 gestational weeks were confirmed at later ultrasound examinations or the pregnancy did not continue (in four cases due to termination of pregnancy and in one case spontaneous miscarriage before first trimester morphology ultrasound). Conclusion Detection of fetal abnormalities is possible before 11 weeks of gestation. Early suspicion is more likely in cases of major structural abnormalities. | ||
| 700 | 1 | |a Rolnik, Daniel Lorber |4 aut | |
| 700 | 1 | |a Fernando, Shavi |4 aut | |
| 700 | 1 | |a Menezes, Melody |4 aut | |
| 700 | 1 | |a Ramkrishna, Jayshree |4 aut | |
| 700 | 1 | |a Costa, Fabricio |4 aut | |
| 700 | 1 | |a Meagher, Simon |4 aut | |
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