Identification of the association of CD28+ CD244+ Tc17/IFN‐γ cells with chronic hepatitis C virus infection
Abstract CD8+ T cells play multiple and complex immunological roles including antiviral, regulatory, and exhaustive effects in hepatitis C virus (HCV) infected patients. Some CD8+ T‐cell subsets were confirmed to be closely related to HCV infection such as T CM, T EM, T EM RA, Tc17, and CD8+ Treg. Herein, we report a new subset of interleukin (IL)‐17/interferon (IFN)‐γ producing CD8+ T (Tc17/IFN‐γ) cells that markedly correlate with CD28+ CD244+ cells, IL‐17 levels, and HCV RNA in HCV patients. During early treatment with peg‐IFN‐a2a plus ribavirin, the imbalance of these Tc17/IFN‐γ cells could be partially restored, together with normalized serum alanine aminotransferase but not aspartate transaminase. Also, we analyzed the dynamic change of the percentage of this T cells subset in patients with different outcome after 4‐week course of treatment with peg‐IFN‐a2a plus ribavirin and found that the percentage of CD8+ CD28+ CD244+ T cells significantly decreased in recovered patients but not in nonrecovered patients. In vitro, CD28+ CD244+ T cells were the only CD8+ T‐cell group that secreted both IL‐17 and IFN‐γ in this axis and blockade with anti‐CD244 antibodies significantly reduced cytokine production. Taken together, this study demonstrates that the frequency and regulatory functions of CD28+ CD244+ Tc17/IFN‐γ cells may play an important role in persistent HCV infection..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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| Enthalten in: |
Journal of Medical Virology - 92(2020), 12, Seite 3534-3544 |
| Beteiligte Personen: |
Han, Wenzheng [VerfasserIn] |
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| BKL: |
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| Anmerkungen: |
© 2020 Wiley Periodicals LLC |
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| Umfang: |
11 |
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| doi: |
10.1002/jmv.26205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract CD8+ T cells play multiple and complex immunological roles including antiviral, regulatory, and exhaustive effects in hepatitis C virus (HCV) infected patients. Some CD8+ T‐cell subsets were confirmed to be closely related to HCV infection such as T CM, T EM, T EM RA, Tc17, and CD8+ Treg. Herein, we report a new subset of interleukin (IL)‐17/interferon (IFN)‐γ producing CD8+ T (Tc17/IFN‐γ) cells that markedly correlate with CD28+ CD244+ cells, IL‐17 levels, and HCV RNA in HCV patients. During early treatment with peg‐IFN‐a2a plus ribavirin, the imbalance of these Tc17/IFN‐γ cells could be partially restored, together with normalized serum alanine aminotransferase but not aspartate transaminase. Also, we analyzed the dynamic change of the percentage of this T cells subset in patients with different outcome after 4‐week course of treatment with peg‐IFN‐a2a plus ribavirin and found that the percentage of CD8+ CD28+ CD244+ T cells significantly decreased in recovered patients but not in nonrecovered patients. In vitro, CD28+ CD244+ T cells were the only CD8+ T‐cell group that secreted both IL‐17 and IFN‐γ in this axis and blockade with anti‐CD244 antibodies significantly reduced cytokine production. Taken together, this study demonstrates that the frequency and regulatory functions of CD28+ CD244+ Tc17/IFN‐γ cells may play an important role in persistent HCV infection. | ||
| 700 | 1 | |a Li, Jiajia |4 aut | |
| 700 | 1 | |a Zhou, Hongchang |4 aut | |
| 700 | 1 | |a Qian, Jing |4 aut | |
| 700 | 1 | |a Tong, Zhaowei |4 aut | |
| 700 | 1 | |a Wang, Weihong |4 aut | |
| 700 | 1 | |a Zhong, Jianfeng |4 aut | |
| 700 | 1 | |a Xue, Tao |4 aut | |
| 700 | 1 | |a Chen, Qing |4 aut | |
| 700 | 1 | |a Yao, Yunliang |4 aut | |
| 700 | 1 | |a Shao, Shengwen |4 aut | |
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