Comparison of three sedation models for same‐day painless bidirectional endoscopy : A multicenter randomized controlled trial
Abstract Background and Aim We investigated the most beneficial propofol sedation model for same‐day painless bidirectional endoscopy (BDE). Methods Asymptomatic participants scheduled for same‐day painless BDE examination from October 2020 to September 2021 were randomized to three groups: sedated esophagogastroduodenoscopy followed by unsedated colonoscopy (Group A); sedated esophagogastroduodenoscopy followed by sedated colonoscopy (Group B); and sedated esophagogastroduodenoscopy followed by sedated insertion colonoscopy (Group C). Patient discomfort, colonoscopy performance, doses of propofol, cardiovascular stress, anesthesia resuscitation, and sedation‐related adverse events were evaluated. Results A total of 3200 participants were analyzed. Baseline demographics, patient discomfort, cecal intubation rate, adenoma detection rate and sedation‐related adverse events were similar in the three groups. Propofol dose was the lowest in Group A (137.65 ± 36.865 mg) compared with Group B (177.71 ± 40.112 mg, P < 0.05) and Group C (161.63 ± 31.789 mg, P < 0.05). Decline in vital signs was most obvious in Group B during the procedure ( P < 0.05). Recovery time was the shortest in Group A (5.01 ± 1.404 min) compared with Group B (9.51 ± 2.870 min, P < 0.05) and Group C (5.83 ± 2.594 min, P < 0.05); discharge time was the shortest in Group A (3.53 ± 1.685 min) compared with Group B (11.29 ± 5.172 min, P < 0.05) and Group C (6.47 ± 2.338 min, P < 0.05). Adenomas per positive patient of Group A (2.29 ± 1.055) and Group C (2.28 ± 0.931) were more than that in Group B (2.11 ± 0.946, P < 0.05). Conclusions Sedated esophagogastroduodenoscopy followed by unsedated colonoscopy is the superior model for same‐day painless BDE with the benefits of satisfactory patient comfort, reduced sedation dose, less cardiovascular stress, faster recovery, shorter discharge time and high colonoscopy quality..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Journal of Gastroenterology and Hepatology - 37(2022), 8, Seite 1603-1609 |
| Beteiligte Personen: |
Sui, Yue [VerfasserIn] |
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| BKL: |
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| Anmerkungen: |
© 2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
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| Umfang: |
7 |
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| doi: |
10.1111/jgh.15901 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Background and Aim We investigated the most beneficial propofol sedation model for same‐day painless bidirectional endoscopy (BDE). Methods Asymptomatic participants scheduled for same‐day painless BDE examination from October 2020 to September 2021 were randomized to three groups: sedated esophagogastroduodenoscopy followed by unsedated colonoscopy (Group A); sedated esophagogastroduodenoscopy followed by sedated colonoscopy (Group B); and sedated esophagogastroduodenoscopy followed by sedated insertion colonoscopy (Group C). Patient discomfort, colonoscopy performance, doses of propofol, cardiovascular stress, anesthesia resuscitation, and sedation‐related adverse events were evaluated. Results A total of 3200 participants were analyzed. Baseline demographics, patient discomfort, cecal intubation rate, adenoma detection rate and sedation‐related adverse events were similar in the three groups. Propofol dose was the lowest in Group A (137.65 ± 36.865 mg) compared with Group B (177.71 ± 40.112 mg, P < 0.05) and Group C (161.63 ± 31.789 mg, P < 0.05). Decline in vital signs was most obvious in Group B during the procedure ( P < 0.05). Recovery time was the shortest in Group A (5.01 ± 1.404 min) compared with Group B (9.51 ± 2.870 min, P < 0.05) and Group C (5.83 ± 2.594 min, P < 0.05); discharge time was the shortest in Group A (3.53 ± 1.685 min) compared with Group B (11.29 ± 5.172 min, P < 0.05) and Group C (6.47 ± 2.338 min, P < 0.05). Adenomas per positive patient of Group A (2.29 ± 1.055) and Group C (2.28 ± 0.931) were more than that in Group B (2.11 ± 0.946, P < 0.05). Conclusions Sedated esophagogastroduodenoscopy followed by unsedated colonoscopy is the superior model for same‐day painless BDE with the benefits of satisfactory patient comfort, reduced sedation dose, less cardiovascular stress, faster recovery, shorter discharge time and high colonoscopy quality. | ||
| 700 | 1 | |a Chen, Xing |4 aut | |
| 700 | 1 | |a Ma, Ting |4 aut | |
| 700 | 1 | |a Lu, Junhui |4 aut | |
| 700 | 1 | |a Xiao, Tao |4 aut | |
| 700 | 1 | |a Wang, Zhenzhen |4 aut | |
| 700 | 1 | |a Wen, Qing |4 aut | |
| 700 | 1 | |a Wang, Guanfeng |4 aut | |
| 700 | 1 | |a Jia, Hui |4 aut | |
| 700 | 1 | |a Cao, Fengzhen |4 aut | |
| 700 | 1 | |a Wu, Xiaopeng |4 aut | |
| 700 | 1 | |a Zhang, Yiping |4 aut | |
| 700 | 1 | |a Hao, Junlian |4 aut | |
| 700 | 1 | |a Wang, Naping |4 aut | |
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