Novel Schiff bases–based thiophenes : Design, synthesis and biological evaluation
Abstract2‐amino‐5‐(3‐fluoro‐4‐methoxyphenyl)thiophene‐3‐carbonitrile derivatives have been synthesized from 1‐(3‐fluoro‐4‐methoxyphenyl)ethanone, malononitrile, mild base, and sulfur powder using the Gewald method through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of their elemental analyses, IR,1 H NMR,13 C NMR, and mass spectral data, and then synthesized compounds were screened for their in vitro antimicrobial activity. Among them, derivatives3b(thiphene),3f(pyrazole), and3d(halogen) showed good activity and remaining derivatives exhibited moderate activity..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Journal of the Chinese Chemical Society - 67(2020), 7, Seite 1278-1288 |
| Beteiligte Personen: |
Puthran, Divyaraj [VerfasserIn] |
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| BKL: |
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| Anmerkungen: |
© 2020 The Chemical Society Located in Taipei & Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim |
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| Umfang: |
11 |
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| doi: |
10.1002/jccs.201900388 |
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| funding: |
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| 520 | |a Abstract2‐amino‐5‐(3‐fluoro‐4‐methoxyphenyl)thiophene‐3‐carbonitrile derivatives have been synthesized from 1‐(3‐fluoro‐4‐methoxyphenyl)ethanone, malononitrile, mild base, and sulfur powder using the Gewald method through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of their elemental analyses, IR,1 H NMR,13 C NMR, and mass spectral data, and then synthesized compounds were screened for their in vitro antimicrobial activity. Among them, derivatives3b(thiphene),3f(pyrazole), and3d(halogen) showed good activity and remaining derivatives exhibited moderate activity. | ||
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