Structural and functional diversity calls for a new classification of ABC transporters
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:594 |
|---|---|
| Enthalten in: |
FEBS Letters - 594(2020), 23, Seite 3767-3775 |
| Beteiligte Personen: |
Thomas, Christoph [VerfasserIn] |
|---|
| BKL: |
|---|
| Anmerkungen: |
© 2020 Federation of European Biochemical Societies |
|---|
| Umfang: |
10 |
|---|
| doi: |
10.1002/1873-3468.13935 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
WLY005657520 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | WLY005657520 | ||
| 003 | DE-627 | ||
| 005 | 20230307152502.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230215s2020 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1002/1873-3468.13935 |2 doi | |
| 028 | 5 | 2 | |a FEB2_FEB213935.xml |
| 035 | |a (DE-627)WLY005657520 | ||
| 035 | |a (WILEY)FEB213935 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 082 | 0 | 4 | |a 570 |a 530 |a 610 |q ASE |
| 084 | |a 35.70 |2 bkl | ||
| 100 | 1 | |a Thomas, Christoph |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Structural and functional diversity calls for a new classification of ABC transporters |
| 264 | 1 | |c 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © 2020 Federation of European Biochemical Societies | ||
| 520 | |a Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs. | ||
| 700 | 1 | |a Aller, Stephen G. |4 aut | |
| 700 | 1 | |a Beis, Konstantinos |4 aut | |
| 700 | 1 | |a Carpenter, Elisabeth P. |4 aut | |
| 700 | 1 | |a Chang, Geoffrey |4 aut | |
| 700 | 1 | |a Chen, Lei |4 aut | |
| 700 | 1 | |a Dassa, Elie |4 aut | |
| 700 | 1 | |a Dean, Michael |4 aut | |
| 700 | 1 | |a Duong Van Hoa, Franck |4 aut | |
| 700 | 1 | |a Ekiert, Damian |4 aut | |
| 700 | 1 | |a Ford, Robert |4 aut | |
| 700 | 1 | |a Gaudet, Rachelle |4 aut | |
| 700 | 1 | |a Gong, Xin |4 aut | |
| 700 | 1 | |a Holland, I. Barry |4 aut | |
| 700 | 1 | |a Huang, Yihua |4 aut | |
| 700 | 1 | |a Kahne, Daniel K. |4 aut | |
| 700 | 1 | |a Kato, Hiroaki |4 aut | |
| 700 | 1 | |a Koronakis, Vassilis |4 aut | |
| 700 | 1 | |a Koth, Christopher M. |4 aut | |
| 700 | 1 | |a Lee, Youngsook |4 aut | |
| 700 | 1 | |a Lewinson, Oded |4 aut | |
| 700 | 1 | |a Lill, Roland |4 aut | |
| 700 | 1 | |a Martinoia, Enrico |4 aut | |
| 700 | 1 | |a Murakami, Satoshi |4 aut | |
| 700 | 1 | |a Pinkett, Heather W. |4 aut | |
| 700 | 1 | |a Poolman, Bert |4 aut | |
| 700 | 1 | |a Rosenbaum, Daniel |4 aut | |
| 700 | 1 | |a Sarkadi, Balazs |4 aut | |
| 700 | 1 | |a Schmitt, Lutz |4 aut | |
| 700 | 1 | |a Schneider, Erwin |4 aut | |
| 700 | 1 | |a Shi, Yigong |4 aut | |
| 700 | 1 | |a Shyng, Show‐Ling |4 aut | |
| 700 | 1 | |a Slotboom, Dirk J. |4 aut | |
| 700 | 1 | |a Tajkhorshid, Emad |4 aut | |
| 700 | 1 | |a Tieleman, D. Peter |4 aut | |
| 700 | 1 | |a Ueda, Kazumitsu |4 aut | |
| 700 | 1 | |a Váradi, András |4 aut | |
| 700 | 1 | |a Wen, Po‐Chao |4 aut | |
| 700 | 1 | |a Yan, Nieng |4 aut | |
| 700 | 1 | |a Zhang, Peng |4 aut | |
| 700 | 1 | |a Zheng, Hongjin |4 aut | |
| 700 | 1 | |a Zimmer, Jochen |4 aut | |
| 700 | 1 | |a Tampé, Robert |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t FEBS Letters |g 594(2020), 23, Seite 3767-3775 |w (DE-627)WLY00564819X |x 18733468 |7 nnns |
| 773 | 1 | 8 | |g volume:594 |g year:2020 |g number:23 |g pages:3767-3775 |g extent:10 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_WLY | ||
| 936 | b | k | |a 35.70 |q ASE |
| 951 | |a AR | ||
| 952 | |d 594 |j 2020 |e 23 |h 3767-3775 |g 10 | ||