Magneto‐Based Synergetic Therapy for Implant‐Associated Infections via Biofilm Disruption and Innate Immunity Regulation
Abstract Implant‐associated infections (IAIs) are a common cause of orthopedic surgery failure due to microbial biofilm‐induced antibiotic‐resistance and innate immune inactivation. Thus, the destruction of microbial biofilm plays a key role in reducing IAIs. Herein, first, a magneto‐based synergetic therapy (MST) is proposed and demonstrated against IAIs based on biofilm destruction. Under an alternating magnetic field (AMF), CoFe2 O4MnFe2 O4 nanoparticles (MNPs), with a rather strong magnetic hyperthermal capacity, can generate sufficient thermal effect to cause dense biofilm dispersal. Loosened biofilms provide channels through which nitrosothiol‐coated MNPs (MNP‐SNOs) can penetrate. Subsequently, thermosensitive nitrosothiols rapidly release nitric oxide (NO) inside biofilms, thus efficiently killing sessile bacteria under the magnetothermal effect of MNPs. More importantly, MNP‐SNOs can trigger macrophage‐related immunity to prevent the relapse of IAIs by exposing the infected foci to a consistent innate immunomodulatory effect. The notable anti‐infection effect of this nanoplatform is also confirmed in a rat IAI model. This work presents the promising potential of combining magnetothermal therapy with immunotherapy, for the effective and durable control and elimination of IAIs..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
|---|---|
| Enthalten in: |
Advanced Science - 8(2021), 6 |
| Beteiligte Personen: |
Wang, Jiaxing [VerfasserIn] |
|---|
| Anmerkungen: |
© 2021 Wiley‐VCH GmbH |
|---|
| Umfang: |
12 |
|---|
| doi: |
10.1002/advs.202004010 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
WLY00047245X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | WLY00047245X | ||
| 003 | DE-627 | ||
| 005 | 20230307091856.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230209s2021 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1002/advs.202004010 |2 doi | |
| 028 | 5 | 2 | |a ADVS_ADVS2336.xml |
| 035 | |a (DE-627)WLY00047245X | ||
| 035 | |a (WILEY)ADVS2336 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 082 | 0 | 4 | |a 500 |a 600 |a 624 |q ASE |
| 082 | 0 | 4 | |a 500 |a 600 |a 624 |q ASE |
| 100 | 1 | |a Wang, Jiaxing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Magneto‐Based Synergetic Therapy for Implant‐Associated Infections via Biofilm Disruption and Innate Immunity Regulation |
| 264 | 1 | |c 2021 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © 2021 Wiley‐VCH GmbH | ||
| 520 | |a Abstract Implant‐associated infections (IAIs) are a common cause of orthopedic surgery failure due to microbial biofilm‐induced antibiotic‐resistance and innate immune inactivation. Thus, the destruction of microbial biofilm plays a key role in reducing IAIs. Herein, first, a magneto‐based synergetic therapy (MST) is proposed and demonstrated against IAIs based on biofilm destruction. Under an alternating magnetic field (AMF), CoFe2 O4MnFe2 O4 nanoparticles (MNPs), with a rather strong magnetic hyperthermal capacity, can generate sufficient thermal effect to cause dense biofilm dispersal. Loosened biofilms provide channels through which nitrosothiol‐coated MNPs (MNP‐SNOs) can penetrate. Subsequently, thermosensitive nitrosothiols rapidly release nitric oxide (NO) inside biofilms, thus efficiently killing sessile bacteria under the magnetothermal effect of MNPs. More importantly, MNP‐SNOs can trigger macrophage‐related immunity to prevent the relapse of IAIs by exposing the infected foci to a consistent innate immunomodulatory effect. The notable anti‐infection effect of this nanoplatform is also confirmed in a rat IAI model. This work presents the promising potential of combining magnetothermal therapy with immunotherapy, for the effective and durable control and elimination of IAIs. | ||
| 700 | 1 | |a Wang, Lingtian |4 aut | |
| 700 | 1 | |a Pan, Jiong |4 aut | |
| 700 | 1 | |a Zhao, Jinhui |4 aut | |
| 700 | 1 | |a Tang, Jin |4 aut | |
| 700 | 1 | |a Jiang, Dajun |4 aut | |
| 700 | 1 | |a Hu, Ping |4 aut | |
| 700 | 1 | |a Jia, Weitao |4 aut | |
| 700 | 1 | |a Shi, Jianlin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advanced Science |g 8(2021), 6 |w (DE-627)WLY000452548 |x 21983844 |7 nnns |
| 773 | 1 | 8 | |g volume:8 |g year:2021 |g number:6 |g extent:12 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_WLY | ||
| 951 | |a AR | ||
| 952 | |d 8 |j 2021 |e 6 |g 12 | ||