Effects of the tetravanadate [$ V_{4} $$ O_{12} $]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes
The aim to access linked tetravanadate [$ V_{4} $$ O_{12} $]4− anion with mixed copper(II) complexes, using α-amino acids and phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)($ OH_{2} $)]2[Cu(dmb)(Gly)]2[$ V_{4} $$ O_{12} $]·$ 9H_{2} $O (1) [Cu(dmb)(Lys)]2[$ V_{4} $$ O_{12} $]·$ 8H_{2} $O (2), [Cu(dmp)2][$ V_{4} $$ O_{12} $]·$ C_{2} $$ H_{5} $OH·$ 11H_{2} $O (3), and [Cu(dmp)(Gly)Cl]·$ 2H_{2} $O (4), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline. The [$ V_{4} $$ O_{12} $]4− anion is functionalized with mixed copper(II) units in 1 and 2; while in 3, it acts as a counterion of two [Cu(dmp)]2+ units. Compound 4 crystallized as a unit that did not incorporate the vanadium cluster. All compounds present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble 3 and 4 by UV–Vis spectroscopy in cell culture medium confirmed the robustness of 3, while 4 appears to undergo ligand scrambling over time, resulting partially in the stable species [Cu(dmp)2]+ that was also identified by electrospray ionization mass spectrometry at m/z = 479. The in vitro cytotoxicity activity of 3 and 4 was determined in six cancer cell lines; the healthy cell line COS-7 was also included for comparative purposes. MCF-7 cells were more sensitive to compound 3 with an $ IC_{50} $ value of 12 ± 1.2 nmol. The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive oxygen species formation. Both compounds inhibited cell migration at 5 µM in wound-healing assays using MCF-7, PC-3, and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems. Graphical abstract.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
|---|---|
| Enthalten in: |
Journal of biological inorganic chemistry - 29(2024), 1 vom: 04. Jan., Seite 139-158 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sánchez-Lara, Eduardo [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| BKL: | |
|---|---|
| Themen: |
Antiproliferative properties |
| Anmerkungen: |
© The Author(s) 2024 |
|---|
| doi: |
10.1007/s00775-023-02035-9 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR055453007 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR055453007 | ||
| 003 | DE-627 | ||
| 005 | 20240409064716.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240409s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00775-023-02035-9 |2 doi | |
| 035 | |a (DE-627)SPR055453007 | ||
| 035 | |a (SPR)s00775-023-02035-9-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 570 |q VZ |
| 082 | 0 | 4 | |a 540 |q VZ |
| 084 | |a 35.79 |2 bkl | ||
| 084 | |a 35.49 |2 bkl | ||
| 100 | 1 | |a Sánchez-Lara, Eduardo |e verfasserin |0 (orcid)0000-0002-8282-0103 |4 aut | |
| 245 | 1 | 0 | |a Effects of the tetravanadate [$ V_{4} $$ O_{12} $]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2024 | ||
| 520 | |a The aim to access linked tetravanadate [$ V_{4} $$ O_{12} $]4− anion with mixed copper(II) complexes, using α-amino acids and phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)($ OH_{2} $)]2[Cu(dmb)(Gly)]2[$ V_{4} $$ O_{12} $]·$ 9H_{2} $O (1) [Cu(dmb)(Lys)]2[$ V_{4} $$ O_{12} $]·$ 8H_{2} $O (2), [Cu(dmp)2][$ V_{4} $$ O_{12} $]·$ C_{2} $$ H_{5} $OH·$ 11H_{2} $O (3), and [Cu(dmp)(Gly)Cl]·$ 2H_{2} $O (4), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline. The [$ V_{4} $$ O_{12} $]4− anion is functionalized with mixed copper(II) units in 1 and 2; while in 3, it acts as a counterion of two [Cu(dmp)]2+ units. Compound 4 crystallized as a unit that did not incorporate the vanadium cluster. All compounds present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble 3 and 4 by UV–Vis spectroscopy in cell culture medium confirmed the robustness of 3, while 4 appears to undergo ligand scrambling over time, resulting partially in the stable species [Cu(dmp)2]+ that was also identified by electrospray ionization mass spectrometry at m/z = 479. The in vitro cytotoxicity activity of 3 and 4 was determined in six cancer cell lines; the healthy cell line COS-7 was also included for comparative purposes. MCF-7 cells were more sensitive to compound 3 with an $ IC_{50} $ value of 12 ± 1.2 nmol. The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive oxygen species formation. Both compounds inhibited cell migration at 5 µM in wound-healing assays using MCF-7, PC-3, and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems. Graphical abstract | ||
| 650 | 4 | |a Vanadate–copper complexes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magneto-structural correlations |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cytotoxic activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Wound healing |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antiproliferative properties |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Favela, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Tzian, Kitze |e verfasserin |4 aut | |
| 700 | 1 | |a Monroy-Torres, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Romo-Pérez, Adriana |e verfasserin |4 aut | |
| 700 | 1 | |a Ramírez-Apan, María Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Flores-Alamo, Marcos |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Diéguez, Antonio |e verfasserin |0 (orcid)0000-0003-3198-5378 |4 aut | |
| 700 | 1 | |a Cepeda, Javier |e verfasserin |0 (orcid)0000-0002-0147-1360 |4 aut | |
| 700 | 1 | |a Castillo, Ivan |e verfasserin |0 (orcid)0000-0002-4876-4339 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of biological inorganic chemistry |d Springer International Publishing, 1996 |g 29(2024), 1 vom: 04. Jan., Seite 139-158 |w (DE-627)SPR007730381 |w (DE-600)1464026-0 |x 1432-1327 |7 nnns |
| 773 | 1 | 8 | |g volume:29 |g year:2024 |g number:1 |g day:04 |g month:01 |g pages:139-158 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00775-023-02035-9 |m X:VERLAG |x 0 |z kostenfrei |3 Volltext |
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 35.79 |q VZ |
| 936 | b | k | |a 35.49 |q VZ |
| 951 | |a AR | ||
| 952 | |d 29 |j 2024 |e 1 |b 04 |c 01 |h 139-158 | ||