High-performance pyrite nano-catalyst driven photothermal/chemodynamic synergistic therapy for Osteosarcoma
Abstract Osteosarcoma (OS) is an aggressive bone tumor with strong invasiveness, rapid metastasis, and dreadful mortality. Chemotherapy is a commonly used approach for OS treatment but is limited by the development of drug resistance and long-term adverse effects. To date, OS still lacks the curative treatment. Herein, we fabricated pyrite-based nanoparticles ($ FeS_{2} $CP NPs) as synergetic therapeutic platform by integrating photothermal therapy (PTT) and chemo-dynamic therapy (CDT) into one system. The synthetic $ FeS_{2} $@CP NPs showed superior Fenton reaction catalytic activity. $ FeS_{2} $@CP NPs-based CDT efficaciously eradicated the tumor cells by initiating dual-effect of killing of apoptosis and ferroptosis. Furthermore, the generated heat from $ FeS_{2} $@CP under near-infrared region II (NIR-II) laser irradiation could not only inhibit tumor’s growth, but also promote tumor cell apoptosis and ferroptosis by accelerating •OH production and GSH depletion. Finally, the photothermal/NIR II-enhanced CDT synergistic therapy showed excellent osteosarcoma treatment effects both in vitro and in vivo with negligible side effects. Overall, this work provided a high-performance and multifunctional Fenton catalyst for osteosarcoma synergistic therapy, which provided a pathway for the clinical application of PTT augmented CDT..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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Enthalten in: |
Journal of nanobiotechnology - 22(2024), 1 vom: 01. Apr. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Li, Meirong [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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BKL: | |
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Themen: |
Chemodynamic therapy |
Anmerkungen: |
© The Author(s) 2024 |
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doi: |
10.1186/s12951-024-02419-2 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
SPR05537445X |
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520 | |a Abstract Osteosarcoma (OS) is an aggressive bone tumor with strong invasiveness, rapid metastasis, and dreadful mortality. Chemotherapy is a commonly used approach for OS treatment but is limited by the development of drug resistance and long-term adverse effects. To date, OS still lacks the curative treatment. Herein, we fabricated pyrite-based nanoparticles ($ FeS_{2} $CP NPs) as synergetic therapeutic platform by integrating photothermal therapy (PTT) and chemo-dynamic therapy (CDT) into one system. The synthetic $ FeS_{2} $@CP NPs showed superior Fenton reaction catalytic activity. $ FeS_{2} $@CP NPs-based CDT efficaciously eradicated the tumor cells by initiating dual-effect of killing of apoptosis and ferroptosis. Furthermore, the generated heat from $ FeS_{2} $@CP under near-infrared region II (NIR-II) laser irradiation could not only inhibit tumor’s growth, but also promote tumor cell apoptosis and ferroptosis by accelerating •OH production and GSH depletion. Finally, the photothermal/NIR II-enhanced CDT synergistic therapy showed excellent osteosarcoma treatment effects both in vitro and in vivo with negligible side effects. Overall, this work provided a high-performance and multifunctional Fenton catalyst for osteosarcoma synergistic therapy, which provided a pathway for the clinical application of PTT augmented CDT. | ||
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700 | 1 | |a Wang, Minghua |4 aut | |
700 | 1 | |a Huang, Junfeng |4 aut | |
700 | 1 | |a Tang, Shiqi |4 aut | |
700 | 1 | |a Yang, Jingyu |4 aut | |
700 | 1 | |a Xu, Zhourui |4 aut | |
700 | 1 | |a Xu, Gaixia |4 aut | |
700 | 1 | |a Chen, Xin |4 aut | |
700 | 1 | |a Liu, Jia |4 aut | |
700 | 1 | |a Yang, Chengbin |4 aut | |
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