The role of adjuvant chemotherapy in patients with H3K27 altered diffuse midline gliomas: a multicentric retrospective study
Purpose Adult Diffuse midline glioma (DMG) is a very rare disease. DMGs are currently treated with radiotherapy and chemotherapy even if only a few retrospective studies assessed the impact on overall survival (OS) of these approaches. Methods We carried out an Italian multicentric retrospective study of adult patients with H3K27-altered DMG to assess the effective role of systemic therapy in the treatment landscape of this rare tumor type. Results We evaluated 49 patients from 6 Institutions. The median age was 37.3 years (range 20.1–68.3). Most patients received biopsy as primary approach (n = 30, 61.2%) and radiation therapy after surgery (n = 39, 79.6%). 25 (51.0%) of patients received concurrent chemotherapy and 26 (53.1%) patients received adjuvant temozolomide. In univariate analysis, concurrent chemotherapy did not result in OS improvement while adjuvant temozolomide was associated with longer OS (21.2 vs. 9.0 months, HR 0.14, 0.05–0.41, p < 0.001). Multivariate analysis confirmed the role of adjuvant chemotherapy (HR 0.1, 95%CI: 0.03–0.34, p = 0.003). In patients who progressed after radiation and/or chemotherapy the administration of a second-line systemic treatment had a significantly favorable impact on survival (8.0 vs. 3.2 months, HR 0.2, 95%CI 0.1–0.65, p = 0.004). Conclusion In our series, adjuvant treatment after radiotherapy can be useful in improving OS of patients with H3K27-altered DMG. When feasible another systemic treatment after treatment progression could be proposed..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:167 |
|---|---|
| Enthalten in: |
Journal of neuro-oncology - 167(2024), 1 vom: März, Seite 145-154 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Di Nunno, Vincenzo [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
Adjuvant treatment |
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s11060-024-04589-3 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR055334865 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR055334865 | ||
| 003 | DE-627 | ||
| 005 | 20240329064647.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240329s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11060-024-04589-3 |2 doi | |
| 035 | |a (DE-627)SPR055334865 | ||
| 035 | |a (SPR)s11060-024-04589-3-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 44.81 |2 bkl | ||
| 084 | |a 44.90 |2 bkl | ||
| 100 | 1 | |a Di Nunno, Vincenzo |e verfasserin |0 (orcid)0000-0003-4441-9834 |4 aut | |
| 245 | 1 | 0 | |a The role of adjuvant chemotherapy in patients with H3K27 altered diffuse midline gliomas: a multicentric retrospective study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Purpose Adult Diffuse midline glioma (DMG) is a very rare disease. DMGs are currently treated with radiotherapy and chemotherapy even if only a few retrospective studies assessed the impact on overall survival (OS) of these approaches. Methods We carried out an Italian multicentric retrospective study of adult patients with H3K27-altered DMG to assess the effective role of systemic therapy in the treatment landscape of this rare tumor type. Results We evaluated 49 patients from 6 Institutions. The median age was 37.3 years (range 20.1–68.3). Most patients received biopsy as primary approach (n = 30, 61.2%) and radiation therapy after surgery (n = 39, 79.6%). 25 (51.0%) of patients received concurrent chemotherapy and 26 (53.1%) patients received adjuvant temozolomide. In univariate analysis, concurrent chemotherapy did not result in OS improvement while adjuvant temozolomide was associated with longer OS (21.2 vs. 9.0 months, HR 0.14, 0.05–0.41, p < 0.001). Multivariate analysis confirmed the role of adjuvant chemotherapy (HR 0.1, 95%CI: 0.03–0.34, p = 0.003). In patients who progressed after radiation and/or chemotherapy the administration of a second-line systemic treatment had a significantly favorable impact on survival (8.0 vs. 3.2 months, HR 0.2, 95%CI 0.1–0.65, p = 0.004). Conclusion In our series, adjuvant treatment after radiotherapy can be useful in improving OS of patients with H3K27-altered DMG. When feasible another systemic treatment after treatment progression could be proposed. | ||
| 650 | 4 | |a H3K27 altered glioma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diffuse midline glioma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a DMG |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adult DMG |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adjuvant treatment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Concomitant chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Radiotherapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lombardi, Giuseppe |4 aut | |
| 700 | 1 | |a Simonelli, Matteo |4 aut | |
| 700 | 1 | |a Minniti, Giuseppe |4 aut | |
| 700 | 1 | |a Mastronuzzi, Angela |4 aut | |
| 700 | 1 | |a Di Ruscio, Valentina |4 aut | |
| 700 | 1 | |a Corrà, Martina |4 aut | |
| 700 | 1 | |a Padovan, Marta |4 aut | |
| 700 | 1 | |a Maccari, Marta |4 aut | |
| 700 | 1 | |a Caccese, Mario |4 aut | |
| 700 | 1 | |a Simonetti, Giorgia |4 aut | |
| 700 | 1 | |a Berlendis, Arianna |4 aut | |
| 700 | 1 | |a Farinotti, Mariangela |4 aut | |
| 700 | 1 | |a Pollo, Bianca |4 aut | |
| 700 | 1 | |a Antonelli, Manila |4 aut | |
| 700 | 1 | |a Di Muzio, Antonio |4 aut | |
| 700 | 1 | |a Dipasquale, Angelo |4 aut | |
| 700 | 1 | |a Asioli, Sofia |4 aut | |
| 700 | 1 | |a De Biase, Dario |4 aut | |
| 700 | 1 | |a Tosoni, Alicia |4 aut | |
| 700 | 1 | |a Silvani, Antonio |4 aut | |
| 700 | 1 | |a Franceschi, Enrico |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Springer US, 1983 |g 167(2024), 1 vom: März, Seite 145-154 |w (DE-627)SPR016154118 |w (DE-600)2007293-4 |x 1573-7373 |7 nnns |
| 773 | 1 | 8 | |g volume:167 |g year:2024 |g number:1 |g month:03 |g pages:145-154 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s11060-024-04589-3 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.81 |q VZ |
| 936 | b | k | |a 44.90 |q VZ |
| 951 | |a AR | ||
| 952 | |d 167 |j 2024 |e 1 |c 03 |h 145-154 | ||