Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults

Background Chronic kidney disease (CKD) is linked to immunity and inflammation. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are novel measures for gauging an individual’s systemic inflammatory activity. We aim to investigate the potential associations between them. Methods This study encompassed a cohort of 40,937 adults from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. SII and SIRI were log2-transformed before conducting regression analysis, considering that these inflammatory markers were right skewed distributed. Weighted logistic regression models assessed the association of log2-SII and log2-SIRI levels with CKD prevalence. Weighted Cox regression models were utilized to estimate the risk of death. Subgroup analyses were performed to further clarify the effects of other covariates on the associations. Sensitivity analyses were performed to assess the robustness of our results. Results 6986 participants with CKD were recorded, and 2818 patients died during a mean follow-up time of 100 months. After adjusting for all covariates, the highest level of log2-SII increased the CKD incidence (odds ratio [OR]: 1.47, 95% confidence intervals [CI]: 1.32–1.65, P < 0.001), as well as log2-SIRI (OR: 1.79, 95% CI 1.60–2.01, P < 0.001) when compared with the lowest level reference group. The highest level of log2-SII significantly increased all-cause mortality (hazard risk [HR]: 1.29; 95% CI 1.13–1.48, P < 0.001), cardiovascular mortality (HR: 1.61, 95% CI 1.25–2.09, P < 0.001), and hypertension mortality (HR: 1.73, 95% CI 1.23–2.42, P = 0.001) in CKD patients. Additionally, the positive associations were also found between log2-SIRI and all cause (HR: 1.54, 95% CI 1.35–1.76, P < 0.001), cardiovascular (HR: 1.90, 95% CI 1.38–2.60, P < 0.001), and hypertension mortality (HR: 2.15, 95% CI 1.56–2.94, P < 0.001). Subgroup analyses unveiled variations in these effects among different populations. Conclusion There existed a substantial association of SII and SIRI levels with CKD prevalence, as well as mortality in patients with CKD in the U.S. population..

Medienart:	E-Artikel

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	Zur Gesamtaufnahme - volume:73
Enthalten in:	Inflammation research - 73(2024), 4 vom: 15. März, Seite 655-667

Sprache:	Englisch

Beteiligte Personen:	Huang, Peixian [VerfasserIn] Mai, Yanpei [VerfasserIn] Zhao, Jun [VerfasserIn] Yi, Yushan [VerfasserIn] Wen, Yaqing [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.45
Themen:	Chronic kidney disease Mortality NHANES Systemic immune-inflammation index Systemic inflammation response index

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© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s00011-024-01861-0

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PPN (Katalog-ID):	SPR05531418X