Managing Gastrointestinal Symptoms Resulting from Treatment with Trofinetide for Rett Syndrome: Caregiver and Nurse Perspectives

Abstract Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder mainly affecting female individuals. Trofinetide was recently approved as the first treatment for RTT, largely on the basis of results from the phase 3 LAVENDER trial, in which trofinetide showed improvements in core symptoms of RTT compared with placebo. However, gastrointestinal (GI) symptoms such as diarrhea and vomiting were commonly reported side effects, and taste was also a reported issue. The objective of this article is to describe the perspectives of five caregivers of girls in trofinetide clinical trials as well as those of three nurse trial coordinators, with a focus on management of GI symptoms of trofinetide treatment. Audio Abstract available for this article. Au_dUK2uM7LoCMhe6W7-94Audio Abstract: Jane Lane provides an overview and discusses key findings of the article titled “Managing Gastrointestinal Symptoms Resulting from Treatment with Trofinetide for Rett Syndrome: Caregiver and Nurse Perspectives.” (MP4 83274 KB).

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:41

Enthalten in:

Advances in therapy - 41(2024), 4 vom: 20. Feb., Seite 1305-1317

Sprache:

Englisch

Beteiligte Personen:

Moore, Rebecca [VerfasserIn]
Poulsen, Joshua [VerfasserIn]
Reardon, Lindsay [VerfasserIn]
Samples-Morris, Candice [VerfasserIn]
Simmons, Holly [VerfasserIn]
Ramsey, Keri M. [VerfasserIn]
Whatley, Meagan L. [VerfasserIn]
Lane, Jane B. [VerfasserIn]

Links:

Volltext [kostenfrei]

Themen:

Diarrhea
Rett syndrome
Taste
Trofinetide
Vomiting

Anmerkungen:

© The Author(s) 2024

doi:

10.1007/s12325-024-02782-4

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

SPR055270190