Association of preoperative neutrophil–lymphocyte ratios with the emergence delirium in pediatric patients after tonsillectomy and adenoidectomy: an observational prospective study
Purpose The study aimed to investigate potential risk factors for emergence delirium (ED) in pediatric patients after tonsillectomy and adenoidectomy (T&A). Methods This prospective, single-center observational study enrolled children aged 3–7 years who underwent T&A under general anesthesia. ED was assessed according to DSM-IV or V criteria. Receiver operating characteristic curve analysis was performed to evaluate the predicative and cut-off values of risk factors, including age, preoperative anxiety level, postoperative pain and neutrophil–lymphocyte ratio (NLR) for ED. Univariate and multivariate logistic regression analyses were performed to investigate risk factors for ED. Results 94 pediatric patients who underwent T&A were enrolled and 19 developed ED (an incidence of 25.3%). Receiver operating characteristic analysis indicated that preoperative NLR was a significant predictor of ED with a cut-off value of 0.8719 and an area under the curve (AUC) of 0.671 (95% confidence interval (CI) 0.546–0.796, P = 0.022). Preoperative NLR (< 0.8719) and postoperative pain were independent risk factors associated with ED (odds ratio: 0.168, 95% CI 0.033–0.858, P = 0.032; odds ratio: 7.298, 95% CI 1.563–34.083, P = 0.011) according to multivariate logistic regression analysis. Conclusions Preoperative NLR level and postoperative pain were independent risk factors for ED in pediatric patients undergoing T&A..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
|---|---|
| Enthalten in: |
Journal of anesthesia - 38(2024), 2 vom: 24. Jan., Seite 206-214 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Feng, Bei [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
| Anmerkungen: |
© The Author(s) under exclusive licence to Japanese Society of Anesthesiologists 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s00540-023-03303-3 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR055221491 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR055221491 | ||
| 003 | DE-627 | ||
| 005 | 20240321064649.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240321s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00540-023-03303-3 |2 doi | |
| 035 | |a (DE-627)SPR055221491 | ||
| 035 | |a (SPR)s00540-023-03303-3-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 44.66 |2 bkl | ||
| 100 | 1 | |a Feng, Bei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of preoperative neutrophil–lymphocyte ratios with the emergence delirium in pediatric patients after tonsillectomy and adenoidectomy: an observational prospective study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) under exclusive licence to Japanese Society of Anesthesiologists 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Purpose The study aimed to investigate potential risk factors for emergence delirium (ED) in pediatric patients after tonsillectomy and adenoidectomy (T&A). Methods This prospective, single-center observational study enrolled children aged 3–7 years who underwent T&A under general anesthesia. ED was assessed according to DSM-IV or V criteria. Receiver operating characteristic curve analysis was performed to evaluate the predicative and cut-off values of risk factors, including age, preoperative anxiety level, postoperative pain and neutrophil–lymphocyte ratio (NLR) for ED. Univariate and multivariate logistic regression analyses were performed to investigate risk factors for ED. Results 94 pediatric patients who underwent T&A were enrolled and 19 developed ED (an incidence of 25.3%). Receiver operating characteristic analysis indicated that preoperative NLR was a significant predictor of ED with a cut-off value of 0.8719 and an area under the curve (AUC) of 0.671 (95% confidence interval (CI) 0.546–0.796, P = 0.022). Preoperative NLR (< 0.8719) and postoperative pain were independent risk factors associated with ED (odds ratio: 0.168, 95% CI 0.033–0.858, P = 0.032; odds ratio: 7.298, 95% CI 1.563–34.083, P = 0.011) according to multivariate logistic regression analysis. Conclusions Preoperative NLR level and postoperative pain were independent risk factors for ED in pediatric patients undergoing T&A. | ||
| 650 | 4 | |a Children |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Emergence delirium |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Risk factor |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Guo, Yuhao |4 aut | |
| 700 | 1 | |a Tang, Shaling |4 aut | |
| 700 | 1 | |a Zhang, Tie |4 aut | |
| 700 | 1 | |a Gao, Yubo |4 aut | |
| 700 | 1 | |a Ni, Xinli |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of anesthesia |d Springer Nature Singapore, 1987 |g 38(2024), 2 vom: 24. Jan., Seite 206-214 |w (DE-627)SPR006778119 |w (DE-600)1481564-3 |x 1438-8359 |7 nnns |
| 773 | 1 | 8 | |g volume:38 |g year:2024 |g number:2 |g day:24 |g month:01 |g pages:206-214 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00540-023-03303-3 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.66 |q VZ |
| 951 | |a AR | ||
| 952 | |d 38 |j 2024 |e 2 |b 24 |c 01 |h 206-214 | ||