Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients

Background Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have a significant impact on patients' quality of life. In the present manuscript, we investigate the association between IBD and MS in a German cohort of general practice patients. These results may have important implications for the screening and management of patients with IBD, as well as for further research into the pathophysiological mechanisms underlying both disorders. Methods 4,934 individuals with IBD (11,140 with Crohn’s disease (CD) and 13,794 with ulcerative colitis (UC)) as well as 24,934 propensity score matched individuals without IBD were identified from the Disease Analyzer database (IQVIA). A subsequent diagnosis of MS was analyzed as a function of IBD using Cox regression models. Results After 10 years of follow-up, 0.9% and 0.7% of CD and UC patients but only 0.5% and 0.3% of matched non-IBD pairs were diagnosed with MS, respectively ($ p_{CD} $ = 0.002 and $ p_{UC} $ < 0.001). Both CD (HR: 2.09; 95% CI 1.28–3.39) and UC (HR: 2.35; 95% CI 1.47–3.78) were significantly associated with a subsequent MS diagnosis. Subgroup analysis revealed that the association between both CD and UC and MS was more pronounced among male patients. Conclusion The results of our analysis suggest a notable association between IBD and a subsequent MS diagnosis. These findings warrant further pathophysiological investigation and may have clinical implications for the screening of IBD patients in the future..

Key summary Summarise the established knowledge on this subjectThere is a growing body of evidence suggesting a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS).However, epidemiological data of large real-word cohorts on this potential association are scarceIn the present manuscript, we investigate the association between IBD and MS in a large cohort of over 24.000 outpatients in Germany. What are the significant and/or new findings of this study?Within a 10-year follow-up period, the incidence of MS was significantly higher among Crohn’s disease (CD, 0.9% vs 0.5%) and ulcerative colitis (UC) patients (0.7% vs 0.3%) compared to matched non-IBD patients.Both CD (HR: 2.09; 95% CI 1.28–3.39) and UC (HR: 2.35; 95% CI 1.47–3.78) were significantly associated with a subsequent MS diagnosis in regression analysis.Subgroup analysis revealed that the association between both CD and UC and MS was more pronounced among male patients.These findings warrant further pathophysiological investigation and may have clinical implications for the screening of IBD patients in the future..

Medienart:	E-Artikel

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	Zur Gesamtaufnahme - volume:29
Enthalten in:	European journal of medical research - 29(2024), 1 vom: 20. März

Sprache:	Englisch

Beteiligte Personen:	Yaqubi, Kaneschka [VerfasserIn] Kostev, Karel [VerfasserIn] Klein, Isabel [VerfasserIn] Schüssler, Sofia [VerfasserIn] May, Petra [VerfasserIn] Luedde, Tom [VerfasserIn] Roderburg, Christoph [VerfasserIn] Loosen, Sven H. [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	CD Crohn’s disease IBD MS Neurodegenerative disease UC Ulcerative colitis

Anmerkungen:	© The Author(s) 2024

doi:	10.1186/s40001-024-01776-w

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	SPR05521715X