Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy
Background The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)—particularly with respect to galactose-deficient IgA1 (Gd-IgA1)—has not been fully elucidated. Methods Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group. Results Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05). Conclusion Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Clinical and experimental nephrology - 28(2023), 3 vom: 09. Okt., Seite 192-200 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ito, Seigo [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
-positive |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Japanese Society of Nephrology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s10157-023-02411-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR054849411 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054849411 | ||
| 003 | DE-627 | ||
| 005 | 20240222091202.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240222s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10157-023-02411-4 |2 doi | |
| 035 | |a (DE-627)SPR054849411 | ||
| 035 | |a (SPR)s10157-023-02411-4-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ito, Seigo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Japanese Society of Nephrology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Background The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)—particularly with respect to galactose-deficient IgA1 (Gd-IgA1)—has not been fully elucidated. Methods Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group. Results Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05). Conclusion Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1. | ||
| 650 | 4 | |a IgA nephropathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Periodontal disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Galactose-deficient IgA1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a -positive |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dental caries |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Misaki, Taro |0 (orcid)0000-0002-0476-2550 |4 aut | |
| 700 | 1 | |a Nagasawa, Yasuyuki |4 aut | |
| 700 | 1 | |a Nomura, Ryota |4 aut | |
| 700 | 1 | |a Naka, Shuhei |4 aut | |
| 700 | 1 | |a Fukunaga, Akiko |4 aut | |
| 700 | 1 | |a Matsuoka, Daiki |4 aut | |
| 700 | 1 | |a Matayoshi, Saaya |4 aut | |
| 700 | 1 | |a Matsumoto-Nakano, Michiyo |4 aut | |
| 700 | 1 | |a Nakano, Kazuhiko |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical and experimental nephrology |d [Tokyo] : Springer, 1997 |g 28(2023), 3 vom: 09. Okt., Seite 192-200 |w (DE-627)SPR008960208 |w (DE-600)1499111-1 |x 1437-7799 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2023 |g number:3 |g day:09 |g month:10 |g pages:192-200 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s10157-023-02411-4 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2023 |e 3 |b 09 |c 10 |h 192-200 | ||