Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers
Abstract Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the oropharynx (HPV + OSC) present better survival and respond better to radiotherapy and chemotherapy. Regulatory T cells ($ T_{REG} $) are mainly described as immunosuppressive and protumoral in most solid cancers. However, $ T_{REG} $ are paradoxically associated with a better prognosis in HPV + OSCs. The transcription factor FoxP3 is the basis for the identification of $ T_{REG} $. Among CD4 + FoxP3 + T cells, some have effector functions. A medical hypothesis is formulated here: the existence of a CD137 (4.1BB)-Eomesodermin (Eomes) activated pathway downstream of TCR-specific activation in a subpopulation of CD4 + FoxP3 + T cells may explain this effector function. Evidence suggest that this axis may exist either in CD4 + FoxP3 + T cells or CD8 + T cells. This pathway could lead T cells to strong antitumor cytotoxic activity in a tumor-specific manner. Furthermore, CD137 is one of the most expected targets for the development of agonist immunotherapies. The identification of CD137 + Eomes + FoxP3+/- T cells could be a key element in the selective activation of the most anti-tumor cells in the HPV + OSC microenvironment..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
Molecular medicine - 30(2024), 1 vom: 14. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Baudouin, Robin [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Cancer |
|---|
| Anmerkungen: |
© The Author(s) 2024 |
|---|
| doi: |
10.1186/s10020-024-00796-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR054765072 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054765072 | ||
| 003 | DE-627 | ||
| 005 | 20240215064640.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240215s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s10020-024-00796-w |2 doi | |
| 035 | |a (DE-627)SPR054765072 | ||
| 035 | |a (SPR)s10020-024-00796-w-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Baudouin, Robin |e verfasserin |0 (orcid)0000-0002-4039-4310 |4 aut | |
| 245 | 1 | 0 | |a Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2024 | ||
| 520 | |a Abstract Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the oropharynx (HPV + OSC) present better survival and respond better to radiotherapy and chemotherapy. Regulatory T cells ($ T_{REG} $) are mainly described as immunosuppressive and protumoral in most solid cancers. However, $ T_{REG} $ are paradoxically associated with a better prognosis in HPV + OSCs. The transcription factor FoxP3 is the basis for the identification of $ T_{REG} $. Among CD4 + FoxP3 + T cells, some have effector functions. A medical hypothesis is formulated here: the existence of a CD137 (4.1BB)-Eomesodermin (Eomes) activated pathway downstream of TCR-specific activation in a subpopulation of CD4 + FoxP3 + T cells may explain this effector function. Evidence suggest that this axis may exist either in CD4 + FoxP3 + T cells or CD8 + T cells. This pathway could lead T cells to strong antitumor cytotoxic activity in a tumor-specific manner. Furthermore, CD137 is one of the most expected targets for the development of agonist immunotherapies. The identification of CD137 + Eomes + FoxP3+/- T cells could be a key element in the selective activation of the most anti-tumor cells in the HPV + OSC microenvironment. | ||
| 650 | 4 | |a Cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HPV |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Squamous cell carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T regulator |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a FoxP3+ |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Eomes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymphocytes |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tartour, Eric |4 aut | |
| 700 | 1 | |a Badoual, Cécile |4 aut | |
| 700 | 1 | |a Hans, Stéphane |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular medicine |d [London] : BioMed Central, 1994 |g 30(2024), 1 vom: 14. Feb. |w (DE-627)SPR008052611 |w (DE-600)1475577-4 |x 1528-3658 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2024 |g number:1 |g day:14 |g month:02 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s10020-024-00796-w |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 2024 |e 1 |b 14 |c 02 | ||