Monitoring of Brain Tissue Oxygen Tension in Cardiac Arrest: a Translational Systematic Review from Experimental to Clinical Evidence
Background Cardiac arrest (CA) is a sudden event that is often characterized by hypoxic-ischemic brain injury (HIBI), leading to significant mortality and long-term disability. Brain tissue oxygenation ($ PbtO_{2} $) is an invasive tool for monitoring brain oxygen tension, but it is not routinely used in patients with CA because of the invasiveness and the absence of high-quality data on its effect on outcome. We conducted a systematic review of experimental and clinical evidence to understand the role of $ PbtO_{2} $ in monitoring brain oxygenation in HIBI after CA and the effect of targeted $ PbtO_{2} $ therapy on outcomes. Methods The search was conducted using four search engines (PubMed, Scopus, Embase, and Cochrane), using the Boolean operator to combine mesh terms such as $ PbtO_{2} $, CA, and HIBI. Results Among 1,077 records, 22 studies were included (16 experimental studies and six clinical studies). In experimental studies, $ PbtO_{2} $ was mainly adopted to assess the impact of gas exchanges, drugs, or systemic maneuvers on brain oxygenation. In human studies, $ PbtO_{2} $ was rarely used to monitor the brain oxygen tension in patients with CA and HIBI. $ PbtO_{2} $ values had no clear association with patients’ outcomes, but in the experimental studies, brain tissue hypoxia was associated with increased inflammation and neuronal damage. Conclusions Further studies are needed to validate the effect and the threshold of $ PbtO_{2} $ associated with outcome in patients with CA, as well as to understand the physiological mechanisms influencing $ PbtO_{2} $ induced by gas exchanges, drug administration, and changes in body positioning after CA..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Neurocritical care - 40(2023), 1 vom: 20. Apr., Seite 349-363 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Battaglini, Denise [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Brain oxygen tension |
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| Anmerkungen: |
© Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s12028-023-01721-5 |
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| 520 | |a Background Cardiac arrest (CA) is a sudden event that is often characterized by hypoxic-ischemic brain injury (HIBI), leading to significant mortality and long-term disability. Brain tissue oxygenation ($ PbtO_{2} $) is an invasive tool for monitoring brain oxygen tension, but it is not routinely used in patients with CA because of the invasiveness and the absence of high-quality data on its effect on outcome. We conducted a systematic review of experimental and clinical evidence to understand the role of $ PbtO_{2} $ in monitoring brain oxygenation in HIBI after CA and the effect of targeted $ PbtO_{2} $ therapy on outcomes. Methods The search was conducted using four search engines (PubMed, Scopus, Embase, and Cochrane), using the Boolean operator to combine mesh terms such as $ PbtO_{2} $, CA, and HIBI. Results Among 1,077 records, 22 studies were included (16 experimental studies and six clinical studies). In experimental studies, $ PbtO_{2} $ was mainly adopted to assess the impact of gas exchanges, drugs, or systemic maneuvers on brain oxygenation. In human studies, $ PbtO_{2} $ was rarely used to monitor the brain oxygen tension in patients with CA and HIBI. $ PbtO_{2} $ values had no clear association with patients’ outcomes, but in the experimental studies, brain tissue hypoxia was associated with increased inflammation and neuronal damage. Conclusions Further studies are needed to validate the effect and the threshold of $ PbtO_{2} $ associated with outcome in patients with CA, as well as to understand the physiological mechanisms influencing $ PbtO_{2} $ induced by gas exchanges, drug administration, and changes in body positioning after CA. | ||
| 650 | 4 | |a Brain oxygen tension |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Brain tissue oxygenation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neuromonitoring |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiac arrest |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hypoxic-ischemic brain injury |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Premraj, Lavienraj |4 aut | |
| 700 | 1 | |a Cho, Sung-Min |4 aut | |
| 700 | 1 | |a Taccone, Fabio Silvio |4 aut | |
| 700 | 1 | |a Sekhon, Mypinder |4 aut | |
| 700 | 1 | |a Robba, Chiara |4 aut | |
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