Treatment with catheter ablation for patients with arrhythmia-induced cardiomyopathy caused by atrial fibrillation promises a good prognosis
Abstract Clinical outcomes after catheter ablation in patients with reduced left ventricular (LV) ejection fraction (EF) and atrial fibrillation (AF) remain unclear. This study aimed to explore the clinical outcomes of patients with arrhythmia-induced cardiomyopathy (AIC) and the influence of pharmacological treatment on clinical outcomes in patients with AIC after the procedure. Ninety-six patients with AF with a reduced LVEF (LVEF < 50%, 66.7 ± 10.9 years; 72 males) underwent AF ablation. AIC was defined as patients whose LVEF recovered ≥ 50% after catheter ablation (n = 67) and patients whose LVEF remained reduced were defined as non-AIC (n = 29). During a median follow-up of 25 (13–40) months, Kaplan–Meier analysis demonstrated that patients with AIC were associated with less frequent cardiovascular death (p = 0.025) and hospitalization for worsening heart failure (p < 0.001) than those without AIC. Freedom from AF recurrence was similar between the two groups (p = 0.47). In multivariate analysis, the LV end-diastolic diameter (p = 0.0002) and the $ CHA_{2} %$ DS_{2} $-VASc scores (p = 0.0062) were independent predictors of AIC. Among the 67 patients with AIC, no significant differences in baseline characteristics, except for LV chamber size and cryoballoon use, were observed between patients with AIC with (n = 31) and without renin–angiotensin system (RAS) inhibitors (n = 36). In the Kaplan–Meier analysis, cardiovascular death, hospitalization for worsening heart failure, and AF recurrence after catheter ablation did not differ between patients treated with and without RAS inhibitors (all p > 0.05). Catheter ablation in patients with AIC due to AF is associated with a good post-procedural prognosis. IRB information The study was approved by the Research Ethics Committee of the University of Fukui (No. 20220151) and clinical trial registration (UMIN000050391)..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
|---|---|
| Enthalten in: |
Heart and vessels - 39(2023), 3 vom: 23. Okt., Seite 240-251 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Aoyama, Daisetsu [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Arrhythmia-induced cardiomyopathy |
|---|
| Anmerkungen: |
© Springer Nature Japan KK, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s00380-023-02329-7 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR054703255 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054703255 | ||
| 003 | DE-627 | ||
| 005 | 20240210064638.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240210s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00380-023-02329-7 |2 doi | |
| 035 | |a (DE-627)SPR054703255 | ||
| 035 | |a (SPR)s00380-023-02329-7-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Aoyama, Daisetsu |e verfasserin |0 (orcid)0000-0002-9175-4881 |4 aut | |
| 245 | 1 | 0 | |a Treatment with catheter ablation for patients with arrhythmia-induced cardiomyopathy caused by atrial fibrillation promises a good prognosis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © Springer Nature Japan KK, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Abstract Clinical outcomes after catheter ablation in patients with reduced left ventricular (LV) ejection fraction (EF) and atrial fibrillation (AF) remain unclear. This study aimed to explore the clinical outcomes of patients with arrhythmia-induced cardiomyopathy (AIC) and the influence of pharmacological treatment on clinical outcomes in patients with AIC after the procedure. Ninety-six patients with AF with a reduced LVEF (LVEF < 50%, 66.7 ± 10.9 years; 72 males) underwent AF ablation. AIC was defined as patients whose LVEF recovered ≥ 50% after catheter ablation (n = 67) and patients whose LVEF remained reduced were defined as non-AIC (n = 29). During a median follow-up of 25 (13–40) months, Kaplan–Meier analysis demonstrated that patients with AIC were associated with less frequent cardiovascular death (p = 0.025) and hospitalization for worsening heart failure (p < 0.001) than those without AIC. Freedom from AF recurrence was similar between the two groups (p = 0.47). In multivariate analysis, the LV end-diastolic diameter (p = 0.0002) and the $ CHA_{2} %$ DS_{2} $-VASc scores (p = 0.0062) were independent predictors of AIC. Among the 67 patients with AIC, no significant differences in baseline characteristics, except for LV chamber size and cryoballoon use, were observed between patients with AIC with (n = 31) and without renin–angiotensin system (RAS) inhibitors (n = 36). In the Kaplan–Meier analysis, cardiovascular death, hospitalization for worsening heart failure, and AF recurrence after catheter ablation did not differ between patients treated with and without RAS inhibitors (all p > 0.05). Catheter ablation in patients with AIC due to AF is associated with a good post-procedural prognosis. IRB information The study was approved by the Research Ethics Committee of the University of Fukui (No. 20220151) and clinical trial registration (UMIN000050391). | ||
| 650 | 4 | |a Catheter ablation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Atrial fibrillation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Arrhythmia-induced cardiomyopathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart failure with recovered ejection fraction |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Miyazaki, Shinsuke |4 aut | |
| 700 | 1 | |a Amaya, Naoki |4 aut | |
| 700 | 1 | |a Tama, Naoto |4 aut | |
| 700 | 1 | |a Hasegawa, Kanae |4 aut | |
| 700 | 1 | |a Nomura, Ryohei |4 aut | |
| 700 | 1 | |a Tsuji, Toshihiko |4 aut | |
| 700 | 1 | |a Nakano, Akira |4 aut | |
| 700 | 1 | |a Uzui, Hiroyasu |4 aut | |
| 700 | 1 | |a Tada, Hiroshi |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Heart and vessels |d Tokyo : Springer, 1985 |g 39(2023), 3 vom: 23. Okt., Seite 240-251 |w (DE-627)SPR004550536 |w (DE-600)1481441-9 |x 1615-2573 |7 nnns |
| 773 | 1 | 8 | |g volume:39 |g year:2023 |g number:3 |g day:23 |g month:10 |g pages:240-251 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00380-023-02329-7 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 39 |j 2023 |e 3 |b 23 |c 10 |h 240-251 | ||