Long-acting anti-inflammatory injectable DEX-Gel with sustained release and self-healing properties regulates $ T_{H} $1/$ T_{H} $2 immune balance for minimally invasive treatment of allergic rhinitis
Background Allergic rhinitis (AR) is a prevalent immune-related allergic disease, and corticosteroid nasal sprays serve as the primary treatment for this patient population. However, their short duration of efficacy and frequent administration pose challenges, leading to drug wastage and potential adverse effects. To overcome these limitations, we devised a novel approach to formulate DEX-Gel by incorporating dexamethasone (DEX) into a blend of Pluronic F127, stearic acid (SA), and polyethylene glycol 400 (PEG400) to achieve sustained-release treatment for AR. Results Following endoscopic injection into the nasal mucosa of AR rats, DEX-Gel exhibited sustained release over a 14-day period. In vivo trials employing various assays, such as flow cytometry (FC), demonstrated that DEX-Gel not only effectively managed allergic symptoms but also significantly downregulated helper T-cells ($ T_{H} $) 2 and $ T_{H} $2-type inflammatory cytokines (e.g., interleukins 4, 5, and 13). Additionally, the $ T_{H} $1/$ T_{H} $2 cell ratio was increased. Conclusion This innovative long-acting anti-inflammatory sustained-release therapy addresses the $ T_{H} $1/$ T_{H} $2 immune imbalance, offering a promising and valuable approach for the treatment of AR and other inflammatory nasal diseases. Graphical Abstract.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Journal of nanobiotechnology - 22(2024), 1 vom: 06. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Dai, Li [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
1/T |
|---|
| Anmerkungen: |
© The Author(s) 2024 |
|---|
| doi: |
10.1186/s12951-024-02306-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR054668972 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054668972 | ||
| 003 | DE-627 | ||
| 005 | 20240207064626.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240207s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12951-024-02306-w |2 doi | |
| 035 | |a (DE-627)SPR054668972 | ||
| 035 | |a (SPR)s12951-024-02306-w-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dai, Li |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long-acting anti-inflammatory injectable DEX-Gel with sustained release and self-healing properties regulates $ T_{H} $1/$ T_{H} $2 immune balance for minimally invasive treatment of allergic rhinitis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2024 | ||
| 520 | |a Background Allergic rhinitis (AR) is a prevalent immune-related allergic disease, and corticosteroid nasal sprays serve as the primary treatment for this patient population. However, their short duration of efficacy and frequent administration pose challenges, leading to drug wastage and potential adverse effects. To overcome these limitations, we devised a novel approach to formulate DEX-Gel by incorporating dexamethasone (DEX) into a blend of Pluronic F127, stearic acid (SA), and polyethylene glycol 400 (PEG400) to achieve sustained-release treatment for AR. Results Following endoscopic injection into the nasal mucosa of AR rats, DEX-Gel exhibited sustained release over a 14-day period. In vivo trials employing various assays, such as flow cytometry (FC), demonstrated that DEX-Gel not only effectively managed allergic symptoms but also significantly downregulated helper T-cells ($ T_{H} $) 2 and $ T_{H} $2-type inflammatory cytokines (e.g., interleukins 4, 5, and 13). Additionally, the $ T_{H} $1/$ T_{H} $2 cell ratio was increased. Conclusion This innovative long-acting anti-inflammatory sustained-release therapy addresses the $ T_{H} $1/$ T_{H} $2 immune imbalance, offering a promising and valuable approach for the treatment of AR and other inflammatory nasal diseases. Graphical Abstract | ||
| 650 | 4 | |a Allergic rhinitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sustained-release anti-inflammatory |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a 1/T |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a 2 immune balance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Injectable gel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Minimally invasive treatment |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Liu, Bin |4 aut | |
| 700 | 1 | |a Lin, Jiangtao |4 aut | |
| 700 | 1 | |a Jiang, Yongquan |4 aut | |
| 700 | 1 | |a Li, Yuanyuan |4 aut | |
| 700 | 1 | |a Yao, Zhuowei |4 aut | |
| 700 | 1 | |a Shen, Silin |4 aut | |
| 700 | 1 | |a Jiang, Yiming |4 aut | |
| 700 | 1 | |a Duan, Yourong |4 aut | |
| 700 | 1 | |a Li, Jiping |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of nanobiotechnology |d London : Biomed Central, 2003 |g 22(2024), 1 vom: 06. Feb. |w (DE-627)SPR02945347X |w (DE-600)2100022-0 |x 1477-3155 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2024 |g number:1 |g day:06 |g month:02 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s12951-024-02306-w |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2024 |e 1 |b 06 |c 02 | ||